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Doxycycline hyclate

Catalog #: 4090
9 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4090/50
Doxycycline hyclate | CAS No. 24390-14-5 | Synthetic Metalloprotease Inhibitors
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Description: Broad-spectrum MMP inhibitor; tetracycline derivative

Chemical Name: (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)- 3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo- 1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide hydrochloride hemiethanolate hemihydrate

Purity: ≥92%

Product Details
Citations (9)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Doxycycline hyclate is a broad-spectrum antibiotic and MMP inhibitor; tetracycline derivative. Doxycycline hyclate increases and promotes smooth muscle cell adhesion; inhibits proliferation and migration. Protects the microvasculature by inhibiting plasminogen systems.

For more information about how Doxycycline hyclate may be used, see our protocols: Transdifferentiating Fibroblasts into Neurons, Reprogramming MEFs into Skeletal Muscle Progenitors.

Technical Data

M.Wt:
512.94
Formula:
C22H24N2O8.HCl.0.5C2H6O.0.5H2O
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥92%
Storage:
Store at +4°C
CAS No:
24390-14-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Doxycycline hyclate (internal use), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Doxycycline hyclate

The citations listed below are publications that use Tocris products. Selected citations for Doxycycline hyclate include:

9 Citations: Showing 1 - 9

  1. Controlled X-chromosome dynamics defines meiotic potential of female mouse in vitro germ cells.
    Authors: Mitinori Et al.
    EMBO J  2022;41:e109457
  2. Dynamic spreading of chromatin-mediated gene silencing and reactivation between neighboring genes in single cells.
    Authors: Connor H Et al.
    Elife  2022;11
  3. Two distinct trophectoderm lineage stem cells from human pluripotent stem cells.
    Authors: Balaji M Et al.
    J Biol Chem  2021;296:100386
  4. 3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration.
    Authors: Ruchira Et al.
    Cell Stem Cell  2021;28:846-862.e8
  5. Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.
    Authors: Ling Et al.
    Cell Stem Cell  2021;28:1090-1104.e6
  6. Chromosome compartments on the inactive X guide TAD formation independently of transcription during X-reactivation.
    Authors: Enrique Et al.
    Nat Commun  2021;12:3499
  7. An Update of the Virion Proteome of Kaposi Sarcoma-Associated Herpesvirus.
    Authors: Rukhsana Et al.
    Viruses  2020;12
  8. Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells.
    Authors: Sato Et al.
    Stem Cell Reports  2019;13:352
  9. Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF.
    Authors: Kalous Et al.
    J Neurochem  2012;122:523

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