EB 47
Chemical Name: 5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine dihydrochloride
Purity: ≥99%
Biological Activity
EB 47 is a potent inhibitor of PARP-1 (IC50 = 45 nM). Reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic.
Ferraris et al.
J.Med.Chem., 2010;53:4561 -
The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).
Jagtap et al.
Bioorg.Med.Chem.Lett., 2004;14:81 -
Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes.
Gaymes et al.
Haematologica, 2009;94:638
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for EB 47
The citations listed below are publications that use Tocris products. Selected citations for EB 47 include:
3 Citations: Showing 1 - 3
-
PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier
Authors: Rom Et al.
Journal of Neuroinflammation 2016;13:254
-
The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity.
Authors: Rom Et al.
Dev Biol 2015;6:878
-
Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions.
Authors: Rom Et al.
Front Microbiol 2015;35:28
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for EB 47
There are currently no reviews for this product. Be the first to review EB 47 and earn rewards!
Have you used EB 47?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
