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Epoprostenol

Catalog #: 2989
2 Citations Datasheet / COA / SDS
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2989/10
Epoprostenol | CAS No. 61849-14-7 | Prostanoid Receptor Agonists
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Description: Endogenous IP receptor agonist
Alternative Names: Prostaglandin I2, Prostacyclin

Chemical Name: (5Z,13E,8R,9S,11R,12R,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity

Epoprostenol is an endogenous prostanoid that is a potent agonist at IP prostanoid receptors. Inhibits platelet aggregation and induces vasodilation.

Technical Data

M.Wt:
374.45
Formula:
C20H31NaO5
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Desiccate at -80°C
CAS No:
61849-14-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. PGI2-receptors and molecular mechanisms in platelets and vasculature: state of the art.
    Oliva and Nicosia
    Pharmacol.Res.Comm., 1987;19:735
  2. Comparison of anti-aggregatory effects of PGI2, PGI3 and ilo. on human and rabbit platelets.
    Kobzar et al.
    Cell.Physiol.Biochem., 2001;11:279

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Citations for Epoprostenol

The citations listed below are publications that use Tocris products. Selected citations for Epoprostenol include:

2 Citations: Showing 1 - 2

  1. Inhibition of profibrotic microRNA-21 affects platelets and their releasate.
    Authors: Barwari Et al.
    JCI Insight  2018;3
  2. Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction.
    Authors: Armstrong Et al.
    Blood  2015;126:e11

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