Evans Blue tetrasodium salt

Catalog #: 0845
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
0845/1G

Evans Blue tetrasodium salt | CAS No. 314-13-6 | Glutamate (EAAT) Transporter Inhibitors

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Description: Dye for assessing cell viability and blood brain barrier permeability; also EAAT inhibitor and iGluR antagonist

Chemical Name: 6,6-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)bis[4-amino- 5-hydroxy-1,3-naphthalenedisulphonic acid] tetrasodium salt

Purity: ≥90%

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Product Details

Citations (2)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Evans Blue tetrasodium salt is a potent inhibitor of L-glutamate uptake into synaptic vesicles. Also inhibits AMPA and kainate receptor-mediated currents (IC₅₀ values are 220 and 150 nM respectively). P2X-selective purinoceptor antagonist. Also a non-permeating dye, stains damaged plasma membrane and enters in the cytoplasm and nucleus, used for checking cell viability.

Optical Data for Evans Blue tetrasodium salt

λ_em	680 nm

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Technical Data

M.Wt:

960.82

Formula:

C₃₄H₂₄N₆Na₄O₁₄S₄

Solubility:

Soluble to 10 mM in water

Purity:

≥90%

Storage:

Store at RT

CAS No:

314-13-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Evans blue antagonizes both α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and kainate receptors and modulates desensitization.
Price and Raymond
Mol. Pharmacol., 1996;50:1665
Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transporter.
Roseth et al.
J.Neurochem., 1995;65:96
P₂-purinoceptor antagonists:II blockade of P₂-purinoceptor subtypes and ecto-nucleotidase by compounds related to Evans blue and trypan blue.
Wittenburg et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1996;354:491
Differential modulation of AMPA receptor mediated currents by Evans Blue in postnatal rat hippocampal neurones.
Schurmann et al.
Br.J.Pharmacol., 1997;121:237

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Citations for Evans Blue tetrasodium salt

The citations listed below are publications that use Tocris products. Selected citations for Evans Blue tetrasodium salt include:

2 Citations: Showing 1 - 2

Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.
Authors: Uderhardt Et al.
Cell 2019;177:541
Research articleHemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors.
Authors: Gao Et al.
Virulence 2018;9:1601

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