Famotidine
Chemical Name: 3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)propanimidamide
Purity: ≥98%
Biological Activity
Famotidine is a potent and high affinity histamine H2 receptor biased inverse agonist (Kd = 14 nM, IC50 = 33 nM). Reduces basal receptor activity by 75%. Inhibits Gs-mediated pathways but acts as a partial agonist of β-arrestin recruitment (EC50 = 105 nM). Inhibits gastric acid secretion and histamine-induced mast cell activation. Also inhibits HIV replication in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Effect of a new potent H2-blocker, 3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]-thio]-N2-sulfamoylpropionamidine (YM-11170) on gastric secretion induced by histamine and food in conscious dogs.
Takagi et al.
Arch.Int.Pharmacodyn.Ther., 1982;256:49 -
Effects of H2-receptor antagonists upon physiological acid secretory states in animals.
Pendleton et al.
J.Pharmacol.Exp.Ther., 1985;233:64 -
The effect of histamine type 2 receptor antagonists on human immunodeficiency virus (HIV) replication: identification of a new class of antiviral agents.
Bourinbaiar & Fruhstorfer
Life Sci., 1996;59:365 -
COVID-19: Famotidine, histamine, mast cells, and mechanisms.
Malone et al.
Res.Sq. - Paper not yet peer reviewed, 2020;
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