FITM

Catalog # Availability Size / Price Qty
6859/10
6859/50
FITM | CAS No. 932737-65-0 | Group I mGluR Modulators
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Description: Potent and selective negative allosteric modulator of mGlu1 receptors

Chemical Name: 4-Fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide

Purity: ≥98%

Product Details
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Biological Activity

FITM is a potent and selective negative allosteric modulator of mGlu1 receptors (IC50 = 5.1 nM). Displays >1300-fold selectivity for mGlu1 over other metabotropic glutamate receptors (IC50 values are 7 μM and >10 μM for mGlu5 and mGlu2 or mGlu8, respectively). Antagonizes methamphetamine-induced locomotion in mice.

Technical Data

M.Wt:
371.43
Formula:
C18H18FN5OS
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
932737-65-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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