FR 171113
Chemical Name: 2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid methyl ester
Purity: ≥98%
Biological Activity
FR 171113 is a protease-activated receptor 1 (PAR1) antagonist. Exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM) with no effect on coagulation time.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist.
Kato et al.
Eur.J.Pharmacol., 1999;384:197 -
Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig.
Kato et al.
Eur.J.Pharmacol., 2003;473:163
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Citation for FR 171113
The citations listed below are publications that use Tocris products. Selected citations for FR 171113 include:
1 Citation: Showing 1 - 1
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Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases.
Authors: Eum Et al.
Am J Physiol Gastrointest Liver Physiol 2014;306:G992
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