Furosemide
Chemical Name: 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
Purity: ≥99%
Biological Activity
Furosemide is a loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) symporter. Also acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Residues in transmembrane domains I and II determine γ-aminobutyric acid type AA receptor subtype-selective antagonism by Furos..
Thompson et al.
Mol.Pharmacol., 1999;55:993 -
Anticonvulsant actions of Furos. in vitro.
Gutschmidt et al.
Neuroscience, 1999;91:1471
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Citations for Furosemide
The citations listed below are publications that use Tocris products. Selected citations for Furosemide include:
6 Citations: Showing 1 - 6
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Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension.
Authors: Barbaro
Cell Rep 2017;21(4):1009
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Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity.
Authors: Li Et al.
Cell 2017;168:86
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High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
Authors: Choe Et al.
Autophagy 2015;85:549
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α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Ins in Cerebellar Granule Cells.
Authors: Accardi Et al.
J Neurosci 2015;35:9676
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A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium.
Authors: Angelantonio Et al.
Cell Death Dis 2014;5:e1501
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Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of D.pam during hyperexcited states.
Authors: Deeb Et al.
Eur J Neurosci 2013;38:2453
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