G 28UCM
Chemical Name: 3-(3,4,5-Trihydroxybenzoyloxy)naphthalen-1-yl 3,4,5-trihydroxybenzoate
Purity: ≥98%
Biological Activity
G 28UCM is a FASN inhibitor. Inhibits breast cancer cell proliferation in vitro (IC50 values are 21 - 79 μM), including cell lines resistant to anti-HER2 therapies. Blocks HER2 signaling and induces apoptosis. Inhibits growth of breast cancer xenografts in mice without causing anorexia.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.
Puig et al.
Breast Cancer Res., 2011;13:R131 -
Novel inhibitors of fatty acid synthase with anticancer activity.
Puig et al.
Clin.Cancer Res., 2009;15:7608
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Citation for G 28UCM
The citations listed below are publications that use Tocris products. Selected citations for G 28UCM include:
1 Citation: Showing 1 - 1
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Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication.
Authors: Chu Et al.
Nat.Metab. 2021;3:1466
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