Ganaxolone
Chemical Name: (3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one
Biological Activity
Ganaxolone is a potent positive allosteric modulator of GABA A receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA A receptors (EC 50 values are 94, 122 and 213 nM for α2β1γ2 L α3β1γ2 L and α1β1γ2 L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Characterization of the anticonvulsive properties of ganaxolone (CCD 1044; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high affinity, steroid modulator of the γ-aminobutyric acidA receptor.
Carter et al.
J.Pharmacol.Exp.Ther., 1997;280:1284 -
Effect of ganaxolone in a rodent model of cerebral hematoma.
Lyden et al.
Stroke, 2000;31:169 -
Modification of behavioral effects of drugs in mice by neuroactive steroids.
Ungard et al.
Psychopharmacology, 2000;148:336
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Citation for Ganaxolone
The citations listed below are publications that use Tocris products. Selected citations for Ganaxolone include:
1 Citation: Showing 1 - 1
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Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
Authors: Asiedu Et al.
J Pain 2012;13:546
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