GM 6001
Chemical Name: (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
Purity: ≥95%
Biological Activity
GM 6001 is a broad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (Ki = 0.4 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage.
Shichi et al.
J.Pharmacol.Exp.Ther., 2011;338:701 -
Inhibition of skin fibroblast Col., thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids.
Grobelny et al.
Biochemistry, 1992;31:7152 -
Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells.
Chao et al.
Eur.J.Pharmacol., 2007;573:49
Product Datasheets
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Citations for GM 6001
The citations listed below are publications that use Tocris products. Selected citations for GM 6001 include:
10 Citations: Showing 1 - 10
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Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.
Authors: Kim Et al.
Nat Commun 2018;9:4600
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Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis.
Authors: Luo Et al.
Nat Commun 2018;9:4126
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ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation.
Authors: Schumacher
Cell Death Dis 2017;8:e2622
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Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis.
Authors: Sun Et al.
Cell Physiol Biochem 2017;41:2319
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Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation.
Authors: Conant Et al.
J Neuroinflammation 2017;14:56
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Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function.
Authors: Lahey Et al.
PLoS One 2017;12:e0180259
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TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
Authors: Bras Et al.
PLoS One 2015;330:29
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PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60.
Authors: Leung Et al.
J Immunol 2015;194:2930
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CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells.
Authors: Greene Et al.
Proc Natl Acad Sci U S A 2015;10:e0144133
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STAT induce Ins-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway.
Authors: Son Et al.
Mol Neurodegener 2015;10:56
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