GSK 1838705

Catalog # Availability Size / Price Qty
5111/10
5111/50
GSK 1838705 | CAS No. 1116235-97-2 | Insulin and Insulin-like Receptor Inhibitors
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Description: Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)

Chemical Name: 2-[[2-[[1-[(Dimethylamino)ethanoyl]-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

GSK 1838705 is a potent insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) inhibitor (IC50 values are 1.6 and 2 nM, respectively). Also inhibits anaplastic lymphoma kinase (ALK) (IC50 = 0.5 nM). Displays > 800-fold selectivity for IR, IGFR1 and ALK over a panel of 44 kinases including JNK. Blocks proliferation of cancer cell lines in vitro, and causes complete regression of ALK-dependent tumors in vivo. Orally bioavailable.

Technical Data

M.Wt:
532.57
Formula:
C27H29FN8O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1116235-97-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.

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Citation for GSK 1838705

The citations listed below are publications that use Tocris products. Selected citations for GSK 1838705 include:

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