GSK 2033
Chemical Name: 2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide
Purity: ≥99%
Biological Activity
GSK 2033 is a potent LXR antagonist (pIC50 = 7.5). Enhances T-cell proliferation and blocks T 0901317-antiproliferative activity on T-cells. Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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LXR-mediated inhibition of CD4+ T helper cells.
Solt L, Kamenecka T, Burris T
PLoS ONE, 2012;7(9):e46615. -
Discovery of tertiary sulfonamides as potent liver X receptor antagonists.
Zuercher et al.
J.Med.Chem., 2010;53:3412
Product Datasheets
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Citations for GSK 2033
The citations listed below are publications that use Tocris products. Selected citations for GSK 2033 include:
7 Citations: Showing 1 - 7
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Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB.
Authors: Amaya Et al.
Cell Mol Life Sci 2023;80:96
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Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer.
Authors: Baek Et al.
Oncogene 2021;40:2872-2883
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Listeria monocytogenes-infected human monocytic derived dendritic cells activate Vγ9Vδ2 T cells independently of HMBPP production.
Authors: Keith S Et al.
Sci Rep 2021;11:16347
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The novel rexinoid MSU-42011 is effective for the treatment of preclinical Kras-driven lung cancer.
Authors: Karen T Et al.
Sci Rep 2020;10:22244
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PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells.
Authors: Bruschi Et al.
Hepatol Commun 2019;3:1191
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Phytosterols Inhibit Side-Chain Oxysterol Mediated Activation of LXR in Breast Cancer Cells.
Authors: Hutchinson Et al.
Int J Mol Sci 2019;20
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Differential Effects of Retinoic Acid Concentrations in Regulating Blood-Brain Barrier Properties.
Authors: Bonney
Eneuro 2017;4
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