Home / Fatty Acid Synthase Inhibitors / GSK 2194069

GSK 2194069

Catalog #: 5303
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5303/5
5303/25
GSK 2194069 | CAS No. 1332331-08-4 | Fatty Acid Synthase Inhibitors
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Description: Potent human fatty acid synthase (hFASN) inhibitor

Chemical Name: 4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Purity: ≥99%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

GSK 2194069 is a potent human fatty acid synthase (hFASN) inhibitor (IC50 = 7.7 nM); inhibits hFAS β-ketoacyl reductase activity. Inhibits lipid synthesis and attenuates proliferation of A549 non-small-cell lung cancer cells (EC50 = 15 nM) in vitro. GSK 2194069 also inhibits infection by SARS-CoV-2 (EC50 = 0.9 nM) in vitro.

Technical Data

M.Wt:
428.48
Formula:
C25H24N4O3
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1332331-08-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site.
    Hardwicke et al.
    Nat.Chem.Biol., 2014;10:774

Product Datasheets

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Citations for GSK 2194069

The citations listed below are publications that use Tocris products. Selected citations for GSK 2194069 include:

4 Citations: Showing 1 - 4

  1. Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited.
    Authors: Evan C Et al.
    Nat Metab  2022;4:711-723
  2. Low glycaemic diets alter lipid metabolism to influence tumour growth.
    Authors: Lien Et al.
    Nature  2021;599:302
  3. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication.
    Authors: Chu Et al.
    Nat.Metab.  2021;3:1466
  4. SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait.
    Authors: Wu and Näär
    Sci Rep  2019;9:10369

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