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GSK 329

Catalog #: 7637 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7637/10
GSK 329 | CAS No. 1268490-12-5 | MAPK Inhibitors
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Description: Potent and selective TNNI3K inhibitor, orally bioavailable

Chemical Name: N-[3,5-Dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]urea

Purity: ≥98%

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Biological Activity

GSK 329 is a potent and selective TNNI3K (cardiac troponin I-interacting kinase) inhibitor (IC50 = 10 nM). It exhibits selectivity for TNNI3K over human VEGFR2 (40-fold), p38α (80-fold), B-Raf (>200-fold) and displays >100-fold selectivity over 80% of 185 kinases tested. In vivo, GSK 329 reduces infarct size, ROS levels, and p38 activation in a mouse model of ischemia/reperfusion cardiac injury. This compound is orally bioavailable.

Technical Data

M.Wt:
472.25
Formula:
C19H14Cl2F3N5O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1268490-12-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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