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Guanfacine hydrochloride

Catalog #: 1030
4 Citations Datasheet / COA / SDS
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1030/10
1030/50
Guanfacine hydrochloride | CAS No. 29110-48-3 | Adrenergic alpha-2 Receptor Agonists
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Description: α2A agonist

Chemical Name: [(2,6-Dichlorophenyl)acetyl]guanidine hydrochloride

Purity: ≥99%

Product Details
Citations (4)
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Biological Activity

Guanfacine hydrochloride is a selective α2A-adrenoceptor agonist (Kd = 31 nM). Displays 60-fold selectivity over α2B-adrenoceptors.

Technical Data

M.Wt:
282.56
Formula:
C9H9Cl2N3O.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
29110-48-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  2. Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance.
    Intengan and Smyth
    J.Pharmacol.Exp.Ther., 1997;281:48
  3. Delineation of rat kidney α2A- and α2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an α2A -selective compound.
    Uhlen and Wikberg
    Eur.J.Pharmacol., 1991;202:235
  4. Alpha-2a/d adrenoceptor subtype stimulation by guanf. increases osmolar clearance.
    Intengan and Smyth
    J.Pharmacol.Exp.Ther., 1997;281:48
  5. Delineation of rat kidney α2A- and α2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanf. is an α2A -selective compound.
    Uhlen and Wikberg
    Eur.J.Pharmacol., 1991;202:235

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Citations for Guanfacine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Guanfacine hydrochloride include:

4 Citations: Showing 1 - 4

  1. Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors.
    Authors: Harris Et al.
    J Neurosci  2018;38:8922
  2. Neuritin can normalize neural deficits of Alzheimer's disease.
    Authors: An Et al.
    Cell Death Dis  2014;5:e1523
  3. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.
    Authors: Hamby Et al.
    Pharmacol Res Perspect  2012;32:14489
  4. alpha2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis.
    Authors: Shields Et al.
    Neuroscience  2009;163:339

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