Guangxitoxin 1E
Purity: ≥95%
Biological Activity
Guangxitoxin 1E is a Kv2.1 and Kv2.2 channel blocker (IC50 values are 1-3 nM). Enhances glucose-stimulated insulin secretion from human islets in vitro, but not from islet cells lacking the Kv2.1 channel. Has no significant effect on plasma insulin, glucagon or blood glucose levels in mice, but increases plasma somatostatin levels.Technical Data
(Modifications: Disulfide bridges: 4-19, 11-24, 18-31)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of Ins and somatostatin release from pancreatic islets.
Li et al.
J.Pharmacol.Exp.Ther., 2013;344:407 -
Gating modifier peptides as probes of pancreatic beta-cell physiology.
Herrington
Toxicon, 2007;49:231
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Citation for Guangxitoxin 1E
The citations listed below are publications that use Tocris products. Selected citations for Guangxitoxin 1E include:
1 Citation: Showing 1 - 1
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Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells.
Authors: Il-Whan Et al.
Korean J Physiol Pharmacol 2017;21:415-421
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