Home / Trk Receptor Inhibitors / GW 441756

GW 441756

Catalog #: 2238
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2238/10
2238/50
GW 441756 | CAS No. 504433-23-2 | Trk Receptor Inhibitors
1 Image
Description: Potent, selective TrkA inhibitor

Chemical Name: 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one

Purity: ≥99%

Product Details
Citations (5)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

GW 441756 is a potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.

Technical Data

M.Wt:
275.31
Formula:
C17H13N3O
Solubility:
Soluble to 15 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
504433-23-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.

Background References

  1. Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles.
    Wood et al.
    Bioorg.Med.Chem.Lett., 2004;14:953

Product Datasheets

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Citations for GW 441756

The citations listed below are publications that use Tocris products. Selected citations for GW 441756 include:

5 Citations: Showing 1 - 5

  1. Granulocyte-macrophage colony-stimulating factor receptor expression in clinical pain disorder tissues and role in neuronal sensitization.
    Authors: Donatien Et al.
    Pain Rep  2018;3:e676
  2. Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
    Authors: Rees Et al.
    Oncotarget  2016;12:109
  3. Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells.
    Authors: Lawn Et al.
    Nat Chem Biol  2015;290:3814
  4. Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion.
    Authors: Edwards Et al.
    J Natl Cancer Inst  2011;103:1162
  5. Cellular assays for high-throughput screening for modulators of Trk receptor tyrosine kinases.
    Authors: Wang Et al.
    Curr Chem Genomics  2008;1:27

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