HBX 41108

Catalog # Availability Size / Price Qty
4285/10
HBX 41108 | CAS No. 924296-39-9 | Deubiquitinating Enzyme Inhibitors
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Description: Selective USP7 inhibitor

Chemical Name: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

Purity: ≥98%

Product Details
Citations (6)
Reviews

Biological Activity

HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

Technical Data

M.Wt:
266.64
Formula:
C13H3ClN4O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
924296-39-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research use only under patent license from Hybrigenics S.A.

Background References

  1. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells.
    CollF, Formstecher E, Jacq X et al.
    Mol Cancer Ther
  2. USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock

    PLoS ONE, 2016;11(4):e0154263.
  3. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes.
    Colombo et al.
    ChemMedChem, 2010;5:552
  4. A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
    JM Kim, YS Yang, KH Park, X Ge, R Xu, N Li, M Song, H Chun, S Bok, JF Charles, O Filhol-Coc, B Boldyreff, T Dinter, PB Yu, N Kon, W Gu, T Takarada, MB Greenblatt, JH Shim
    Nat Commun, 2020;11(1):2289.

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Citations for HBX 41108

The citations listed below are publications that use Tocris products. Selected citations for HBX 41108 include:

6 Citations: Showing 1 - 6

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