Heclin

Catalog #: 5433
4 Citations Datasheet / COA / SDS

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5433/10
5433/50

Heclin | CAS No. 890605-54-6 | Ubiquitin Ligase (E3) Inhibitors

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Description: HECT E3 ubiquitin ligase inhibitor

Chemical Name: N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide

Purity: ≥98%

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Product Details

Citations (4)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Heclin is a HECT E3 ubiquitin ligase inhibitor; inhibits Nedd4, Smurf2 and WWP1 (IC₅₀ values are 6.3, 6.8 and 6.9 μM respectively). Selective for HECT-mediated over RING-mediated ubiquitination.

Technical Data

M.Wt:

283.32

Formula:

C₁₇H₁₇NO₃

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

890605-54-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Peptide and small molecule inhibitors of HECT-type ubiquitin ligases.
Mund et al.
Proc.Natl.Acad.Sci.U.S.A., 2014;111:16736

Product Datasheets

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Mass

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M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Heclin

The citations listed below are publications that use Tocris products. Selected citations for Heclin include:

4 Citations: Showing 1 - 4

Tyrphostin AG1024 Suppresses Coronaviral Replication by Downregulating JAK1 via an IR/IGF-1R Independent Proteolysis Mediated by Ndfip1/2_NEDD4-like E3 Ligase Itch.
Authors: Cheng-Wei Et al.
Pharmaceuticals (Basel) 2022;15
Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes.
Authors: Saskia C Et al.
Life Sci Alliance 2020;3
The E3 ubiquitin ligase Smurf2 regulates PARP1 stability to alleviate oxidative stress-induced injury in human umbilical vein endothelial cells.
Authors: Yingxian Et al.
J Cell Mol Med 2020;24:4600-4611
Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na⁺/K⁺-ATPase independent proteolysise
Authors: Yang Et al.
Biochem Pharmacol 2020;180

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