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HODHBt

Catalog #: 6994 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6994/100
HODHBt | CAS No. 28230-32-2 | Antiviral Compounds
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Description: STAT5-SUMO protein-protein interaction inhibitor

Chemical Name: 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one

Purity: ≥98%

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Biological Activity

HODHBt is a STAT5-SUMO protein-protein interaction inhibitor. Blocks SUMOylation of phosphorylated STAT5. Reactivates latent HIV-1 reservoir in central memory T cells (TCM). Increases viral release by ~2.7-fold at a concentration of 100 μM in combination with IL-2 compared to unstimulated cells; reduces size of latent HIV-1 reservoir in vitro.

Technical Data

M.Wt:
163.14
Formula:
C7H5N3O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
28230-32-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation.
    Bosque et al.
    Cell Rep., 2017;18:1324

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