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HU 308

Catalog #: 3088
7 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3088/10
3088/50
HU 308 | CAS No. 256934-39-1 | Cannabinoid R2/CB2 Agonists
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Description: Potent and selective CB2 agonist

Chemical Name: (1S,4S,5S)-4-[4-(1,1-Dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol

Purity: ≥98%

Product Details
Citations (7)
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Biological Activity

HU 308 is a potent and selective CB2 receptor agonist (Ki values are 22.7 nM and > 10 μM for CB2 and CB1 receptors respectively, EC50 = 5.57 nM). Displays antiallodynic activity in the rat hindpaw incision model of postoperative pain. Also neuroprotective and improves motor performance in a mouse model of Huntington's Disease.

Technical Data

M.Wt:
414.62
Formula:
C27H42O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
256934-39-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for HU 308

The citations listed below are publications that use Tocris products. Selected citations for HU 308 include:

7 Citations: Showing 1 - 7

  1. Altered Swimming Behaviors in Zebrafish Larvae Lacking Cannabinoid Receptor 2.
    Authors: Acevedo-Canabal Et al.
    Cannabis Cannabinoid Res  2019;4:88
  2. Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.
    Authors: Sheng Et al.
    Pain Res Manag  2019;2019:1260353
  3. Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages
    Authors: Ke Et al.
    PLoS One  2016;11:e0155076
  4. Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.
    Authors: Presley Et al.
    Brain Res  2015;3:e00159
  5. Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists.
    Authors: Gianella-Borradori Et al.
    Bioorg Med Chem  2015;23:241
  6. Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis.
    Authors: Sardinha Et al.
    Pharmacol Res Perspect  2014;2014:978678
  7. Prospects for cannabinoid therapies in viral encephalitis.
    Authors: Solbrig Et al.
    Proc Natl Acad Sci U S A  2013;1537:273

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