Human APH1A (NP_001071096) VersaClone cDNA

Catalog #: RDC0383 Datasheet / COA / SDS

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RDC0383

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Human APH1A (NP_001071096) VersaClone cDNA Summary

Specifications

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Species

Human

Product Datasheets

Product Datasheet

COA

SDS

Background: APH1A

Anterior pharynx-defective 1 (APH1A) is a widely expressed 36 kDa 7-transmembrane protein found in the endoplasmic reticulum and Golgi. APH1A is a component of the gamma secretase proteolytic complex which cleaves multiple substrates within their transmembrane domains. This activity liberates the intracellular domains of ErbB4, Neuregulin-1, and Notch receptors in addition to the A-beta peptide from the amyloid precursor protein (APP). Alternate splicing generates a short isoform of human APH1a that lacks 18 amino acids at the C-terminus.

Long Name

gamma-Secretase Subunit Anterior Pharynx Defective 1 Homolog A

Entrez Gene IDs

51107 (Human); 100039623 (Mouse)

Alternate Names

6530402N02Rik; anterior pharynx defective 1 homolog A (C. elegans); APH-1; APH1A; APH-1A; aph-1alpha; CGI-78; gamma-secretase subunit APH-1A; Presenilin-stabilization factor; PSF