Human Biglycan Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Biglycan in Human Kidney Array. Biglycan was detected in immersion fixed paraffin-embedded sections of human kidney array using Human Biglycan Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2667) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Background: Biglycan
Biglycan is a small secreted proteoglycan belonging to the leucine-rich repeat (LRR) protein family. It contains a central 12 LRR repeat domain flanked by small cysteine clusters at either side. Two glycosaminoglycans (GAG) chains are attached near the amino terminus. Biglycan binds BMP-4 and Chordin to regulate BMP-4 signaling. It may also be involved in collagen fiber assembly. Human Biglycan shares 98% amino acid sequence homology with mouse Biglycan, 97% sequence homology with rat and bovine Biglycan and 96% sequence homology with canine and equine Biglycan.
Product Datasheets
Citations for Human Biglycan Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Establishment and characterization of matched immortalized human frontal and occipital scalp dermal papilla cell lines from androgenetic alopecia
Authors: Kwack, MH;Hamida, OB;Kim, MK;Kim, MK;Sung, YK;
Scientific reports
Species: Human
Sample Types: Whole Cells
Applications: Immunocytochemistry/ Immunofluorescence -
The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity
Authors: A Minns, Y Qi, K Yamamoto, K Lee, J Ahnström, S Santamaria
The Journal of Biological Chemistry, 2023-02-21;0(0):103048.
Species: N/A
Sample Types: Protein
Applications: Western Blot -
Post-Translational Regulation And Proteolytic Activity Of The Metalloproteinase Adamts8
Authors: S Santamaria, DR Martin, X Dong, K Yamamoto, SS Apte, J Ahnström
The Journal of Biological Chemistry, 2021-10-21;0(0):101323.
Species: Human
Sample Types: Protein
Applications: Western Blot -
Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases
Authors: AF Asega, MC Menezes, D Trevisan-S, D Cajado-Car, L Bertholim, AK Oliveira, A Zelanis, SMT Serrano
Sci Rep, 2020-07-31;10(1):12912.
Species: Mouse
Sample Types: Cell Lysates, Tissue Homogenates
Applications: Western Blot -
Intimal hyperplasia induced by vascular intervention causes lipoprotein retention and accelerated atherosclerosis
Authors: S Kijani, AM Vázquez, M Levin, J Borén, P Fogelstran
Physiol Rep, 2017-07-01;5(14):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis.
Authors: Melchior, John T, Sawyer, Janet K, Kelley, Kathryn, Shah, Ramesh, Wilson, Martha D, Hantgan, Roy R, Rudel, Lawrence
J Lipid Res, 2013-06-26;54(9):2495-503.
Species: Human
Sample Types: Protein
Applications: ChIP -
Resistance of corneal RFUVA-cross-linked collagens and small leucine-rich proteoglycans to degradation by matrix metalloproteinases.
Authors: Zhang Y, Mao X, Schwend T, Littlechild S, Conrad G
Invest Ophthalmol Vis Sci, 2013-02-05;54(2):1014-25.
Species: Human
Sample Types: Protein
Applications: Western Blot -
Renal accumulation of biglycan and lipid retention accelerates diabetic nephropathy.
Authors: Thompson J, Wilson P, Brandewie K, Taneja D, Schaefer L, Mitchell B, Tannock LR
Am. J. Pathol., 2011-06-30;179(3):1179-87.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway.
Authors: Gomez D, Al Haj Zen A, Borges LF, Philippe M, Gutierrez PS, Jondeau G, Michel JB, Vranckx R
J. Pathol., 2009-05-01;218(1):131-42.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-Fr -
Dermatan sulfate proteoglycan biglycan as a potential selectin L/CD44 ligand involved in selective recruitment of peripheral blood CD16(-) natural killer cells into human endometrium.
Authors: Kitaya K, Yasuo T
J. Leukoc. Biol., 2008-12-16;85(3):391-400.
Species: Human
Sample Types: Tissue Homogenates, Whole Tissue
Applications: IHC-P, Western Blot
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