Human CCR6 Antibody
Human CCR6 Antibody Summary
Met1-Met374
Accession # P51684
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
![CCR6 antibody in Human Spleen by Immunohistochemistry (IHC-P). CCR6 antibody in Human Spleen by Immunohistochemistry (IHC-P).](https://resources.rndsystems.com/images/datasheets/antibody/CCR6_MAB195_Immunohistochemistry_6960.jpg)
CCR6 in Human Spleen. CCR6 was detected in immersion fixed paraffin-embedded sections of human spleen using 25 µg/mL Human CCR6 Monoclonal Antibody (Catalog # MAB195) overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained with the Anti-Mouse HRP-AEC Cell & Tissue Staining Kit (red; Catalog # CTS003) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CCR6
CCR6 is a seven transmembrane-spanning G protein-coupled receptor that binds the chemokine MIP-3 alpha and mediates the chemoattraction of B and T lymphocytes.
Product Datasheets
Citations for Human CCR6 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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High CCR6/CCR7 expression and Foxp3+ Treg cell number are positively related to the progression of laryngeal squamous cell carcinoma
Authors: BIN CHEN, DUO ZHANG, JIAN ZHOU, QING LI, LIN ZHOU, SHI-MIN LI et al.
Oncology Reports
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A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis
Authors: Pedro Caballero-Campo, Mariano G. Buffone, Fabian Benencia, José R. Conejo-García, Paolo F. Rinaudo, George L. Gerton
Journal of Cellular Physiology
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Epithelium-innate immune cell axis in mucosal responses to SIV
Authors: Shang L, Duan L, Perkey KE et al.
Mucosal Immunol
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Human Beta-Defensin 2 and 3 Inhibit HIV-1 Replication in Macrophages
Authors: Jennifer P. Bharucha, Lingling Sun, Wuyuan Lu, Suzanne Gartner, Alfredo Garzino-Demo
Frontiers in Cellular and Infection Microbiology
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Multicytokine-producing CD4+ T cells characterize the livers of patients with NASH
Authors: A Woestemeie, P Scognamigl, Y Zhao, J Wagner, F Muscate, C Casar, F Siracusa, F Cortesi, T Agalioti, S Müller, A Sagebiel, L Konczalla, R Wahib, KF Karstens, AD Giannou, A Duprée, S Wolter, MN Wong, AK Mühlig, AA Bielecka, V Bansal, T Zhang, O Mann, VG Puelles, TB Huber, AW Lohse, JR Izbicki, NW Palm, S Bonn, S Huber, N Gagliani
JCI Insight, 2023-01-10;8(1):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Rifaximin Prevents T-Lymphocytes and Macrophages Infiltration in Cerebellum and Restores Motor Incoordination in Rats with Mild Liver Damage
Authors: T Balzano, P Leone, G Ivaylova, MC Castro, L Reyes, C Ramón, M Malaguarne, M Llansola, V Felipo
Biomedicines, 2021-08-12;9(8):.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+B helper T cells in systemic lupus erythematosus
Authors: F Facciotti, P Larghi, R Bosotti, C Vasco, N Gagliani, C Cordiglier, S Mazzara, V Ranzani, E Rottoli, S Curti, A Penatti, B Karnani, Y Kobayashi, M Crosti, M Bombaci, JP van Hambur, G Rossetti, R Gualtierot, M Gerosa, S Gatti, S Torretta, L Pignataro, SW Tas, S Abrignani, M Pagani, F Grassi, PL Meroni, RA Flavell, J Geginat
Proc. Natl. Acad. Sci. U.S.A., 2020-03-17;117(13):7305-7316.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons
Authors: T Balzano, J Forteza, P Molina, J Giner, A Monzó, J Sancho-Jim, A Urios, C Montoliu, V Felipo
Sci Rep, 2018-02-14;8(1):3004.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Circulating CCL20 as a New Biomarker of Abdominal Aortic Aneurysm
Authors: B Soto, T Gallastegi, C Rodríguez, J Martínez-G, JR Escudero, L Vila, M Camacho
Sci Rep, 2017-12-11;7(1):17331.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Role of CCL20/CCR6 and the ERK signaling pathway in lung adenocarcinoma
Authors: XP Zhang, ZJ Hu, AH Meng, GC Duan, QT Zhao, J Yang
Oncol Lett, 2017-10-23;14(6):8183-8189.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
CCR6 is required for ligand-induced CatSper activation in human sperm
Authors: R Diao, T Wang, KL Fok, X Li, Y Ruan, MK Yu, Y Cheng, Y Chen, H Chen, L Mou, X Cai, Y Wang, Z Cai, X Zeng, HC Chan
Oncotarget, 2017-09-05;8(53):91445-91458.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Skewing towards Treg and Th2 responses is a characteristic feature of sustained remission in ANCA-positive granulomatosis with polyangiitis
Authors: W Szczeklik, B Jakie?a, K Wawrzycka-, M Sanak, M Hubalewska, A Padjas, M Surmiak, K Szczeklik, J Sznajd, J Musia?
Eur. J. Immunol, 2017-02-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Analysis of the cross-talk of Epstein-Barr virus-infected B cells with T cells in the marmoset
Authors: J Dunham, N van Driel, BJ Eggen, C Paul, BA 't Hart, JD Laman, YS Kap
Clin Transl Immunology, 2017-02-10;6(2):e127.
Species: Primate
Sample Types: Whole Cells
Applications: Flow Cytometry -
Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization
Authors: Valentina Cecchinato
J. Immunol, 2016-11-28;0(0):.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Tissue
Applications: IHC-P -
CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition
Br J Cancer, 2016-05-05;0(0):.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: Bioassay, Flow Cytometry, IHC-P -
Oxygen regulates human cytotrophoblast migration by controlling chemokine and receptor expression.
Authors: Schanz A, Red-Horse K, Hess A, Baston-Bust D, Heiss C, Krussel J
Placenta, 2014-09-26;35(12):1089-94.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
CCR6 is a prognostic marker for overall survival in patients with colorectal cancer, and its overexpression enhances metastasis in vivo.
Authors: Liu, Jinlin, Ke, Fang, Xu, Zhenyao, Liu, Zhaoyuan, Zhang, Lingyun, Yan, Sha, Wang, Zhe, Wang, Hong, Wang, Honglin
PLoS ONE, 2014-06-30;9(6):e101137.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
CCR6, the sole receptor for the chemokine CCL20, promotes spontaneous intestinal tumorigenesis.
Authors: Nandi, Bisweswa, Pai, Christin, Huang, Qin, Prabhala, Rao H, Munshi, Nikhil C, Gold, Jason S
PLoS ONE, 2014-05-27;9(5):e97566.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Increased Th17/Treg ratio in chronic liver GVHD.
Authors: Malard F, Bossard C, Brissot E, Chevallier P, Guillaume T, Delaunay J, Mosnier J, Moreau P, Gregoire M, Gaugler B, Mohty M
Bone Marrow Transplant, 2014-01-13;49(4):539-44.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Increased plasmacytoid dendritic cells and RORgammat-expressing immune effectors in cutaneous acute graft-versus-host disease.
Authors: Malard F, Bossard C, Brissot E, Chevallier P, Guillaume T, Delaunay J, Mosnier J, Moreau P, Gregoire M, Gaugler B, Mohty M
J Leukoc Biol, 2013-08-29;94(6):1337-43.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency.
Authors: Mazerolles F, Picard C, Kracker S, Fischer A, Durandy A
J Allergy Clin Immunol, 2013-02-10;131(4):1146-56, 1156.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma.
Authors: Miyagaki T, Sugaya M, Suga H, Kamata M, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S
Clin. Cancer Res., 2011-11-02;17(24):7529-38.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Identification of human NK17/NK1 cells.
Authors: Pandya AD, Al-Jaderi Z, Hoglund RA, Holmoy T, Harbo HF, Norgauer J, Maghazachi AA
PLoS ONE, 2011-10-21;6(10):e26780.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells.
Authors: Kim S, Lewis C, Nadel JA
J. Immunol., 2011-02-07;186(6):3392-400.
Species: Human
Sample Types: Whole Cells
Applications: Western Blot -
Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor.
Authors: Charles J, Di Domizio J, Salameire D, Bendriss-Vermare N, Aspord C, Muhammad R, Lefebvre C, Plumas J, Leccia MT, Chaperot L
J. Invest. Dermatol., 2010-03-11;130(6):1646-56.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention.
Authors: Franciszkiewicz K, Le Floc'h A, Jalil A, Vigant F, Robert T, Vergnon I, Mackiewicz A, Benihoud K, Validire P, Chouaib S, Combadiere C, Mami-Chouaib F
Cancer Res., 2009-07-28;69(15):6249-55.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.
Authors: Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S
J. Exp. Med., 2008-12-29;206(1):249-58.
Species: Human
Sample Types: Whole Cells
Applications: Blocking -
Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells.
Authors: Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH
J. Immunol., 2007-09-15;179(6):3724-33.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Characterisation of dendritic cell subsets in lung cancer micro-environments.
Authors: Bergeron A, El-Hage F, Kambouchner M, Lecossier D, Tazi A
Eur. Respir. J., 2006-08-09;28(6):1170-7.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
Authors: Marchal-Somme J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, Crestani B, Soler P
J. Immunol., 2006-05-15;176(10):5735-9.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-Fr -
Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands.
Authors: Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, Stingl G, Rot A, Maurer D
J. Immunol., 2004-12-01;173(11):6592-602.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses.
Authors: Lim HW, Hillsamer P, Kim CH
J. Clin. Invest., 2004-12-01;114(11):1640-9.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Paired synovium and lymph nodes from rheumatoid arthritis patients differ in dendritic cell and chemokine expression.
Authors: Page G, Miossec P
J. Pathol., 2004-09-01;204(1):28-38.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Plasma cell-like morphology of Th1-cytokine-producing cells associated with the loss of CD3 expression.
Authors: Page G, Sattler A, Kersten S, Thiel A, Radbruch A, Miossec P
Am. J. Pathol., 2004-02-01;164(2):409-17.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC-P -
Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL.
Authors: Annels NE, Willemze AJ, van der Velden VH, Faaij CM, van Wering E, Sie-Go DM, Egeler RM, van Tol MJ, Révész T
Blood, 2003-12-04;103(7):2806-8.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells.
Authors: Maki W, Morales RE, Carroll VA, Telford WG, Knibbs RN, Stoolman LM, Hwang ST
J. Immunol., 2002-09-01;169(5):2346-53.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire.
Authors: Campbell J, Qin S, Unutmaz D, Soler D, Murphy K, Hodge M, Wu L, Butcher E
J Immunol, 2001-06-01;166(11):6477-82.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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Antibody was printed on custom arrays and incubated with fluorescently labeled human EDTA plasma