Human CD38 Fluorescein-conjugated Antibody Summary
Met1-Ile300
Accession # P28907
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
![Detection of CD38 antibody in Whole Blood Monocytes antibody by Flow Cytometry. Detection of CD38 antibody in Whole Blood Monocytes antibody by Flow Cytometry.](https://resources.rndsystems.com/images/datasheets/antibody/CD38_FAB2404F_Flow_Cytometry_17873.jpg)
Detection of CD38 in Whole Blood Monocytes by Flow Cytometry. Whole blood monocytes were stained with Mouse Anti-Human CD38 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB2404F, filled histogram) or isotype control antibody (Catalog # IC003F, open histogram). View our protocol for Staining Membrane-associated Proteins.
![Detection of CD38 antibody in Whole Blood Lymphocytes antibody by Flow Cytometry. Detection of CD38 antibody in Whole Blood Lymphocytes antibody by Flow Cytometry.](https://resources.rndsystems.com/images/datasheets/antibody/CD38_FAB2404F_Flow_Cytometry_17874.jpg)
Detection of CD38 in Whole Blood Lymphocytes by Flow Cytometry. Whole blood lymphocytes were stained with Mouse Anti-Human CD38 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB2404F) and Mouse Anti-Human CD3e APC-conjugated Monoclonal Antibody (Catalog # FAB100A). Quadrant markers were set based on control antibody staining. View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
Background: CD38
CD38, also known as ADP-ribosyl cyclase, is a Type II integral membrane protein. The enzyme is able to transform NAD(P)+ into three different products with calcium mobilizing ability, cyclic ADP-ribose, NAADP+, and ADP-ribose (1). CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells (2, 3). Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic beta cells (4, 5).
- Schuber, F. and F.E. Lund (2004) Curr. Mol. Med. 4:249.
- Jackson, D.G. and J.I. Bell (1990) J. Immunol. 144:2811.
- Sun, L. et al. (1999) J. Cell Biol. 146:1161.
- Partida-Sanchez, S. et al. (2001) Nature Med. 7:1209.
- Kato, I. et al. (1995) J. Biol. Chem. 270:30045.
Product Datasheets
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