Human ChemR23 Antibody

Catalog #: MAB362
5 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB362
MAB362-SP

All ChemR23 Antibodies

Product Details

Citations (5)

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human ChemR23 Antibody Summary

Species Reactivity

Human

Specificity

Detects human ChemR23. Stains human ChemR23-transfected cells but not irrelevant transfectants.

Source

Monoclonal Mouse IgG₃ Clone # 84939

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

NS0 mouse myeloma cell line transfected with human ChemR23 Met1-Leu371 Accession # NP_004063

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Flow Cytometry

2.5 µg/10⁶ cells

Human peripheral blood monocytes

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.

Background: ChemR23

ChemR23 is a chemoattractant receptor expressed on dendritic cells and activated macrophages. ChemR23 binds Chemerin and functions as a coreceptor for SIV and some primary HIV-1 strains.

References

Samson, M. et al. (1998) Eur. J. Immunol. 28:1689.

Long Name

Chemokine-like Receptor 1/Orphan G Protein-coupled Receptor ChemR23

Entrez Gene IDs

1240 (Human); 14747 (Mouse); 60669 (Rat)

Alternate Names

CHEMERINR; chemokine receptor-like 1; chemokine-like receptor 1; ChemR23; cmklr1; Dez; Gpcr27; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; MGC126105; MGC126106; orphan G-protein coupled receptor, Dez

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human ChemR23 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages.
Authors: Herova M, Schmid M, Gemperle C, Hersberger M
J Immunol, 2015-01-30;194(5):2330-7.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Chemerin C9 peptide induces receptor internalization through a clathrin-independent pathway.
Authors: Zhou J, Liao D, Zhang S, Cheng N, He H, Ye R
Acta Pharmacol Sin, 2014-03-24;35(5):653-63.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Resolvin E1 and chemokine-like receptor 1 mediate bone preservation.
Authors: Gao L, Faibish D, Fredman G, Herrera B, Chiang N, Serhan C, Van Dyke T, Gyurko R
J Immunol, 2012-12-14;190(2):689-94.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry, ICC
Potential role of chemerin in recruitment of plasmacytoid dendritic cells to diseased skin.
Authors: Skrzeczynska-Moncznik J, Wawro K, Stefanska A, Oleszycka E, Kulig P, Zabel BA, Sulkowski M, Kapinska-Mrowiecka M, Czubak-Macugowska M, Butcher EC, Cichy J
Biochem. Biophys. Res. Commun., 2009-01-23;380(2):323-7.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Characterization of the human chemerin receptor--ChemR23/CMKLR1--as co-receptor for human and simian immunodeficiency virus infection, and identification of virus-binding receptor domains.
Authors: Martensson UE, Fenyo EM, Olde B, Owman C
Virology, 2006-08-10;355(1):6-17.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry