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Human Complement Factor H-related 1/CFHR1 Antibody

Catalog #: MAB4247
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB4247
MAB4247-SP
Product Details
Citations (2)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Complement Factor H-related 1/CFHR1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human Complement Factor H-related 1/CFHR1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) CFHR2 or rhCFHR5 is observed.
Source
Monoclonal Mouse IgG2B Clone # 442127
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Complement Factor H-related 1/CFHR1 Glu19-Ala328 Accession # Q03591
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Purity
Protein A or G purified from hybridoma culture supernatant

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human Complement Factor H-related 1/CFHR1 under non-reducing conditions
Immunoprecipitation
25 µg/mL
Conditioned cell culture medium spiked with Recombinant Human Complement Factor H‑related 1/CFHR1, see our available Western blot detection antibodies

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.

Background: Complement Factor H-related 1/CFHR1

Complement factor H-related protein 1 (CFHR1) is a 43 kDa, secreted member of the factor H family of glycoproteins. It is produced by hepatocytes and circulates as two differentially glycosylated isoforms (37 kDa and 43 kDa). Mature human CFHR1 is 312 aa in length. It contains five approximately 60 aa SCRs (short consensus repeats/CCPs/SUSHI repeats) that basically constitute the entire molecule. CFHR1 may play a role in lipoprotein complexes that bind LPS to neutrophils. There is no reported rodent counterpart to CFHR1. Over aa 19-143 of the CFHR1 precursor, human CFHR2 and CFHR5 show 98% and 86% aa identity, respectively.

Entrez Gene IDs
3078 (Human)
Alternate Names
BTA; CFHL1FHR-1; CFHLCFHR1P; CFHR1; complement factor H-related 1 pseudogene; Complement Factor Hrelated 1; Complement Factor H-related 1; complement factor H-related protein 1; FHR1; FHR1CFHL1P; H factor (complement)-like 1; H factor (complement)-like 2; H factor-like protein 1; H36-1; H36-2; H-factor-like 1; HFL1H36; HFL2; MGC104329

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Citations for Human Complement Factor H-related 1/CFHR1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Complement regulatory proteins CFHR1 and CFHR3 and patient response to anti-CD20 monoclonal antibody therapy
    Clin Cancer Res, 2016-08-15;0(0):.
    Species: Human
    Sample Types: Serum
    Applications: Western Blot
  2. A novel quantitative hemolytic assay coupled with restriction fragment length polymorphisms analysis enabled early diagnosis of atypical hemolytic uremic syndrome and identified unique predisposing mutations in Japan.
    Authors: Yoshida Y, Miyata T, Matsumoto M, Shirotani-Ikejima H, Uchida Y, Ohyama Y, Kokubo T, Fujimura Y
    PLoS ONE, 2015-05-07;10(5):e0124655.
    Species: Human
    Sample Types: Serum
    Applications: Western Blot

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