Human IL-1 RI PE-conjugated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of IL‑1 RI in HUVEC Human Cells by Flow Cytometry. HUVEC human umbilical vein endothelial cells were stained with Goat Anti-Human IL-1 RI PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB269P, filled histogram) or control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: IL-1 RI
Two distinct types of receptors that bind the pleiotropic cytokines IL-1 alpha and IL-1 beta have been described. The IL-1 receptor Type I is an 80 kDa transmembrane protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. IL-1 receptor Type II is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Both receptors are members of the immunoglobulin superfamily and show approximately 28% sequence identity in their extracellular domains. The two receptor types do not heterodimerize into a receptor complex.
An IL-1 receptor accessory protein that can heterodimerize with the Type I receptor in the presence of IL-1 alpha or IL-1 beta but not IL-1ra, was identified (1). This Type I receptor complex appears to mediate all the known IL-1 biological responses. The receptor Type II has a short cytoplasmic domain and does not transduce IL-1 signals. In addition to the membrane-bound form of IL-1 RII, a naturally-occurring soluble form of IL-1 RII has been described. It has been suggested that the Type II receptor, either as the membrane-bound or as the soluble form, serves as a decoy for IL-1 and inhibits IL-1 action by blocking the binding of IL-1 to the signaling Type I receptor complex. Recombinant IL-1 soluble receptor Type I is a potent antagonist of IL-1 action.
Product Datasheets
Citations for Human IL-1 RI PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
12
Citations: Showing 1 - 10
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IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer
Authors: Koncina, E;Nurmik, M;Pozdeev, VI;Gilson, C;Tsenkova, M;Begaj, R;Stang, S;Gaigneaux, A;Weindorfer, C;Rodriguez, F;Schmoetten, M;Klein, E;Karta, J;Atanasova, VS;Grzyb, K;Ullmann, P;Halder, R;Hengstschläger, M;Graas, J;Augendre, V;Karapetyan, YE;Kerger, L;Zuegel, N;Skupin, A;Haan, S;Meiser, J;Dolznig, H;Letellier, E;
Nature communications
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Human TH17 cells engage gasdermin E pores to release IL-1alpha on NLRP3 inflammasome activation
Authors: YY Chao, A Puhach, D Frieser, M Arunkumar, L Lehner, T Seeholzer, A Garcia-Lop, M van der Wa, S Fibi-Smeta, A Dietschman, T Sommermann, T ?ikovi?, L Taher, MS Gresnigt, SJ Vastert, F van Wijk, G Panagiotou, D Krappmann, O Gro beta, CE Zielinski
Nature Immunology, 2023-01-05;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
Authors: HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi
Nat Commun, 2019-02-12;10(1):709.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Regulation of radiosensitivity by 4-methylumbelliferone via the suppression of interleukin-1 in fibrosarcoma cells
Authors: R Saga, K Hasegawa, K Murata, M Chiba, T Nakamura, K Okumura, E Tsuruga, Y Hosokawa
Oncol Lett, 2019-01-29;17(3):3555-3561.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1beta, IFN-beta, and IL-15 Pathways.
Authors: Mattiola I, Pesant M, Tentorio P, Molgora M, Marcenaro E, Lugli E, Locati M, Mavilio D
J Immunol, 2015-08-14;195(6):2818-28.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions.
Authors: Lu L, Lan Q, Li Z, Zhou X, Gu J, Li Q, Wang J, Chen M, Liu Y, Shen Y, Brand D, Ryffel B, Horwitz D, Quismorio F, Liu Z, Li B, Olsen N, Zheng S
Proc Natl Acad Sci U S A, 2014-08-06;111(33):E3432-40.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors.
Authors: Mercer F, Khaitan A, Kozhaya L, Aberg J, Unutmaz D
J Immunol, 2014-06-23;193(3):1047-54.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Differences in PGE2 production between primary human monocytes and differentiated macrophages: role of IL-1beta and TRIF/IRF3.
Authors: Endo Y, Blinova K, Romantseva T, Golding H, Zaitseva M
PLoS ONE, 2014-05-28;9(5):e98517.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Flow Cytometry -
Induction and activation of human Th17 by targeting antigens to dendritic cells via dectin-1.
Authors: Duluc D, Joo H, Ni L, Yin W, Upchurch K, Li D, Xue Y, Klucar P, Zurawski S, Zurawski G, Oh S
J Immunol, 2014-05-16;192(12):5776-88.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
T cell-derived IL-22 amplifies IL-1beta-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes.
Authors: Dalmas E, Venteclef N, Caer C, Poitou C, Cremer I, Aron-Wisnewsky J, Lacroix-Desmazes S, Bayry J, Kaveri S, Clement K, Andre S, Guerre-Millo M
Diabetes, 2014-02-11;63(6):1966-77.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Suppression of TNF-alpha and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27.
Authors: Kalliolias GD, Gordon RA, Ivashkiv LB
J. Immunol., 2010-10-22;185(11):7047-56.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Regulating human Th17 cells via differential expression of IL-1 receptor.
Authors: Lee WW, Kang SW, Choi J
Blood, 2009-11-12;115(3):530-40.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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