Does this Biosimilar antibody have the same sequence as the therapeutic antibody?

Name: Human IL-17RA/IL-17R (Research Grade Brodalumab Biosimilar) Antibody
Brand: R&D Systems
SKU: MAB10547
Price: 429 USD

The Biosimilar antibody has the same variable region and constant region sequence as the therapeutic antibody.

Human IL-17RA/IL-17R (Research Grade Brodalumab Biosimilar) Antibody

Catalog #: MAB10547 Datasheet / COA / SDS

Recombinant Monoclonal Antibody For Research Use Only

Catalog #	Availability	Size / Price	Qty
MAB10547-100
MAB10547-SP

Detection of IL-17RA/IL-17R in K562 human cell line by Flow Cytometry.

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Human IL-17RA/IL-17R (Research Grade Brodalumab Biosimilar) Antibody Summary

Species Reactivity

Human

Specificity

Detects human IL-17RA/IL-17R based on Brodalumab therapeutic antibody. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Brodalumab. This product is for research use only.

Source

Recombinant Monoclonal Human IgG₁ Clone # Hu129

Purification

Protein A or G purified from cell culture supernatant

Immunogen

Human Il-17 Receptor

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Endotoxin Level

<0.10 EU per 1 μg of the antibody by the LAL method.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25 µg/10⁶ cells

K562 human myelogenous leukemia cell line

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of IL-17RA/IL-17R in K562 human cell line by Flow Cytometry. K562 human myelogenous leukemia cell line was stained with Human Anti-Human IL-17RA/IL-17R (Research Grade Brodalumab Biosimilar) Monoclonal Antibody (Catalog # MAB10547, filled histogram) or Human IgG control antibody (open histogram) followed by anti-human IgG APC-conjugated Secondary Antibody (F0135). Staining was performed using our Staining Membrane-associated Proteins protocol.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-17RA/IL-17R

Brodalumab is a human monoclonal antibody designed for the treatment of inflammatory diseases. Brodalumab binds to the interleukin-17 receptor and so prevents interleukin 17 (IL-17) from activating the receptor.

Long Name

Interleukin 17 Receptor

Entrez Gene IDs

23765 (Human); 16172 (Mouse); 312679 (Rat); 486759 (Canine); 101925679 (Cynomolgus Monkey)

Alternate Names

CD217 antigen; CD217; Cdw217; CDw217interleukin 17 receptor; hIL-17R; IL-17 R; IL-17 RA; IL-17 receptor A; IL17RA; IL-17RA; IL-17RAMGC10262; IL17Rinterleukin-17 receptor A; interleukin 17 receptor A

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

FAQs

Does this Biosimilar antibody have the same sequence as the therapeutic antibody?
- The Biosimilar antibody has the same variable region and constant region sequence as the therapeutic antibody.

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