Does this Biosimilar antibody have the same sequence as the therapeutic antibody?

Name: Human Integrin alpha L/CD11a (Research Grade Efalizumab Biosimilar) Antibody
Brand: R&D Systems
SKU: MAB10350
Price: 389 USD

The Biosimilar antibody has the same variable region and constant region sequence as the therapeutic antibody.

Human Integrin alpha L/CD11a (Research Grade Efalizumab Biosimilar) Antibody

Catalog #: MAB10350 Datasheet / COA / SDS

Recombinant Monoclonal Antibody For Research Use Only

Catalog #	Availability	Size / Price	Qty
MAB10350-100
MAB10350-SP

Detection of Integrin aL/CD11a in human PBMC monocytes by Flow Cytometry.

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Human Integrin alpha L/CD11a (Research Grade Efalizumab Biosimilar) Antibody Summary

Species Reactivity

Human

Specificity

Detects Human Integrin alpha L/CD11a in direct ELISAs.

Source

Recombinant Monoclonal Human IgG₁ Clone # Hu103-2

Purification

Protein A or G purified from cell culture supernatant

Immunogen

Human Integrin alpha L/CD11a

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Endotoxin Level

<0.10 EU per 1 μg of the antibody by the LAL method.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25 µg/10⁶ cells

See below

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of Integrin aL/CD11a in human PBMC monocytes by Flow Cytometry. Human PBMC monocytes were stained with Human Anti-Human Integrin aL/CD11a (Research Grade Efalizumab Biosimilar) Monoclonal Antibody (Catalog # MAB10350, filled histogram) or irrelevant antibody (open histogram) followed by APC-conjugated Anti-Human IgG Secondary Antibody (Catalog # F0135). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Integrin alpha L/CD11a

Efalizumab is a biosimilar directed against human Integrin alpha L/CD11a.

Entrez Gene IDs

3683 (Human); 16408 (Mouse); 308995 (Rat)

Alternate Names

CD11 antigen-like family member A; CD11a antigen; CD11a; CD11Aantigen CD11A (p180), lymphocyte function-associated antigen 1, alphapolypeptide; Integrin alpha L; integrin alpha-L; integrin gene promoter; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen1; alpha polypeptide); ITGAL; Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function-associated molecule 1 alpha chain; LFA-1 alpha; LFA-1; LFA1A; LFA-1A; Ly-15; Ly-21; lymphocyte function-associated antigen 1

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

FAQs

Does this Biosimilar antibody have the same sequence as the therapeutic antibody?
- The Biosimilar antibody has the same variable region and constant region sequence as the therapeutic antibody.

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