Human LAP (TGF-beta 1) PE-conjugated Antibody Summary
Leu30-Arg278 (Cys33Ser)
Accession # P01137
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of LAP (TGF-beta 1) in Human Platelets by Flow Cytometry. Human CD41+platelets were stained with Mouse Anti-Human LAP (TGF-beta 1) PE-conjugated Monoclonal Antibody (Catalog # FAB2463P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
Background: LAP (TGF-beta 1)
The TGF‑ beta family includes several related proteins (70‑80% sequence homology) from mammalian, avian, or Xenopus systems that are now designated TGF‑ beta 1, TGF‑ beta 2, TGF‑ beta 1.2, TGF‑ beta 3, TGF‑ beta 4, and TGF‑ beta 5. These proteins are secreted by cells in the form of an inactive complex, referred to as latent TGF-beta, that consists of TGF‑ beta associated non-covalently with a Latency-associated peptide (LAP). These two proteins are synthesized as a single pro-peptide that is cleaved in a post Golgi compartment prior to secretion. Different TGF‑ beta family members are naturally associated with their own distinct LAPs.
Product Datasheets
Citations for Human LAP (TGF-beta 1) PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Suppressive regulatory T cells and latent transforming growth factor-?-expressing macrophages are altered in the peritoneal fluid of patients with endometriosis
Authors: T Hanada, S Tsuji, M Nakayama, S Wakinoue, K Kasahara, F Kimura, T Mori, K Ogasawara, T Murakami
Reprod. Biol. Endocrinol., 2018-02-01;16(1):9.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
A Cellular MicroRNA Facilitates Regulatory T Lymphocyte Development by Targeting the FOXP3 Promoter TATA-Box Motif
Authors: Y Zhang, W Liu, Y Chen, J Liu, K Wu, L Su, W Zhang, Y Jiang, X Zhang, Y Zhang, C Liu, L Tao, B Liu, H Zhang
J. Immunol., 2017-12-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
TGF-beta/atRA-induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation
Authors: JLDS Schiavinat, R Haddad, F Saldanha-A, J Baiochi, AG Araujo, P Santos Sch, DT Covas, MA Zago, RA Panepucci
Sci Rep, 2017-06-15;7(1):3627.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells
Authors: M Lecendreux, G Churlaud, F Pitoiset, A Regnault, TA Tran, R Liblau, D Klatzmann, M Rosenzwajg
PLoS ONE, 2017-01-20;12(1):e0169836.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Human Regulatory T Cells Mediate Transcriptional Modulation of Dendritic Cell Function
Authors: Emily Mavin
J. Immunol, 2016-11-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Impaired circulating CD4+ LAP+ regulatory T cells in patients with acute coronary syndrome and its mechanistic study.
Authors: Zhu Z, Meng K, Zhong Y, Qi L, Mao X, Yu K, Zhang W, Zhu P, Ren Z, Wu B, Ji Q, Wang X, Zeng Q
PLoS ONE, 2014-02-18;9(2):e88775.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Steady state migratory RelB+ langerin+ dermal dendritic cells mediate peripheral induction of antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells.
Authors: Azukizawa H, Dohler A, Kanazawa N, Nayak A, Lipp M, Malissen B, Autenrieth I, Katayama I, Riemann M, Weih F, Berberich-Siebelt F, Lutz MB
Eur. J. Immunol., 2011-04-14;41(5):1420-34.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut.
Authors: Suzuki K, Maruya M, Kawamoto S
Immunity, 2010-07-23;33(1):71-83.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection.
Authors: Mengshol JA, Golden-Mason L, Arikawa T
PLoS ONE, 2010-03-04;5(3):e9504.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Peptide inhibitors of transforming growth factor-beta enhance the efficacy of antitumor immunotherapy.
Authors: Llopiz D, Dotor J, Casares N, Bezunartea J, Diaz-Valdes N, Ruiz M, Aranda F, Berraondo P, Prieto J, Lasarte JJ, Borras-Cuesta F, Sarobe P
Int. J. Cancer, 2009-12-01;125(11):2614-23.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
FAQs
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How do you isolate human platelets for flow cytometry, using Human LAP (TGF-beta 1) Antibody, Catalog # MAB2463, and its conjugates?
We obtain the platelets from blood plasma by collection the top layer after spinning down whole blood. We proceed with a normal surface stain protocol; no special buffers are required.
Reviews for Human LAP (TGF-beta 1) PE-conjugated Antibody
Average Rating: 5 (Based on 1 Review)
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