Home / Oligodendrocyte Marker O4 / Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Antibody

Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Antibody

Catalog #: MAB1326
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MAB1326
MAB1326-SP
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Detection of Oligodendrocyte Marker O4 in Differentiated Rat Cortical Stem Cells by Flow Cytometry.
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Citations (86)
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Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Antibody Summary

Species Reactivity
Human, Mouse, Rat, Chicken
Specificity
Detects human, mouse, rat, and chicken Oligodendrocyte Marker O4.
Source
Monoclonal Mouse IgM Clone # O4
Purification
IgM-specific Affinity-purified from hybridoma culture supernatant
Immunogen
Bovine brain corpus callosum white matter
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Flow Cytometry
0.25 µg/106 cells
See below
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 
Immunocytochemistry
1-10 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of Oligodendrocyte Marker O4 antibody in Differentiated Rat Cortical Stem Cells antibody by Flow Cytometry. View Larger

Detection of Oligodendrocyte Marker O4 in Differentiated Rat Cortical Stem Cells by Flow Cytometry. Rat cortical stem cells (Catalog # NSC001) either differentiated (filled histogram) or undifferentiated (open histogram) were stained with Mouse Anti-Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Monoclonal Antibody (Catalog # MAB1326), followed by PE-conjugated Anti-Mouse IgM Secondary Antibody (Catalog # F0116). View our protocol for Staining Membrane-associated Proteins.

Immunocytochemistry Oligodendrocyte Marker O4 antibody in Differentiated Rat Cortical Stem Cells by Immunocytochemistry (ICC). View Larger

Oligodendrocyte Marker O4 in Differentiated Rat Cortical Stem Cells. Oligodendrocyte Marker O4 was detected in immersion fixed differentiated rat cortical stem cells using 1 µg/mL Mouse Anti-Human/Mouse/ Rat/Chicken Oligodendrocyte Marker O4 Monoclonal Antibody (Catalog # MAB1326) for 3 hours at room temperature. Cells were stained (red). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunocytochemistry Olig2 and Oligodendrocyte Marker O4 antibody in Rat Cortical Stem Cells by Immunocytochemistry (ICC). View Larger

Olig2 and Oligodendrocyte Marker O4 in Rat Cortical Stem Cells. Olig2 and Oligodendrocyte Marker O4 were detected in 7 day differentiated rat cortical stem cells using 10 µg/mL Human Olig2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2418) and 10 µg/mL Mouse Anti-Human/Mouse/Rat/Chicken O4 Monoclonal Antibody (Catalog # MAB1326). Cells were incubated with primary antibodies for 3 hours at room temperature. Cells were stained for Olig2 using the NorthernLights™ 637-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL002), and stained for O4 using an anti-mouse IgM secondary antibody (pseudo-stained green). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunocytochemistry Oligodendrocyte Marker O4 antibody in Rat Cortical Stem Cells by Immunocytochemistry (ICC). View Larger

Oligodendrocyte Marker O4 in Rat Cortical Stem Cells. Oligodendrocyte Marker O4 was detected in immersion fixed 7 day differentiated rat cortical stem cells using 1 µg/mL Mouse Anti-Human/Mouse/ Rat/Chicken Oligodendrocyte Marker O4 Monoclonal Antibody (Catalog # MAB1326) for 3 hours at room temperature. Cells were stained (red) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Oligodendrocyte Marker O4

Oligodendrocytes are myelinating cells in the central nervous system (CNS) and form the myelin sheath of axons to support rapid nerve conduction. Oligodendrocyte Marker O4 is an antigen on the surface of oligodendrocyte progenitors (1, 2). It has been commonly used as the earliest recognized marker specific for the oligodendroglial lineage (3-8).

References
  1. Schachner, M. et al. (1981) Dev. Biol. 83:328.
  2. Bansal, R. et al. (1989) J. Neurosci. Res. 24:548.
  3. Bansal, R. and Pfeiffer, S.E. (1989) Proc. Natl. Acad. Sci. USA 86:6181.
  4. Gard, A. et al. (1995) Dev. Biol. 167:596.
  5. Reynolds, R. and Hardy, R. (1997) J. Neurosci. Res. 47:455.
  6. Ono, K. et al. (1997) J. Neurosci. Res. 48:212.
  7. Pang, Y. et al. (2000) J. Neurosci. Res. 62:510.
  8. Cai, Z. et al. (2001) Brain Res. 898:126.
Alternate Names
Oligodendrocyte Marker O4

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Citations for Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

86 Citations: Showing 1 - 10
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  1. Extracellular vesicles produced by HIV-1 Nef-expressing cells induce myelin impairment and oligodendrocyte damage in the mouse central nervous system
    Authors: Schenck, JK;Karl, MT;Clarkson-Paredes, C;Bastin, A;Pushkarsky, T;Brichacek, B;Miller, RH;Bukrinsky, MI;
    Journal of neuroinflammation
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  2. Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie the Allan-Herndon-Dudley syndrome
    Authors: Salas-Lucia, F;Escamilla, S;Bianco, AC;Dumitrescu, A;Refetoff, S;
    JCI insight
    Species: Human
    Sample Types: Whole Cells
    Applications: Immunocytochemistry
  3. Cellular Modeling of CLN6 with IPSC-derived Neurons and Glia
    Authors: Otero, MG;Kim, J;Kushwaha, YK;Rajewski, A;Nonis, FD;Santiskulvong, C;Bannykh, SI;Oza, H;Farooqi, HMU;Babros, M;Freeman, C;Dupuis, L;Mercimek-Andrews, S;Mendoza-Londono, R;Bresee, C;Adams, DR;Tifft, CJ;Toro, C;Khanlou, N;Gahl, WA;Salamon, N;Pierson, TM;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells
    Applications: Immunocytochemistry
  4. Glial progenitor heterogeneity and key regulators revealed by single-cell RNA sequencing provide insight to regeneration in spinal cord injury
    Authors: Wei, H;Wu, X;Withrow, J;Cuevas-Diaz Duran, R;Singh, S;Chaboub, LS;Rakshit, J;Mejia, J;Rolfe, A;Herrera, JJ;Horner, PJ;Wu, JQ;
    Cell reports
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Immunocytochemistry
  5. Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis
    Authors: M Schepers, D Paes, A Tiane, B Rombaut, E Piccart, L van Veggel, P Gervois, E Wolfs, I Lambrichts, C Brullo, O Bruno, E Fedele, R Ricciarell, C Ffrench-Co, ME Bechler, P van Schaik, W Baron, E Lefevere, K Wasner, A Grünewald, C Verfaillie, P Baeten, B Broux, P Wieringa, N Hellings, J Prickaerts, T Vanmierlo
    Brain, Behavior, and Immunity, 2022-12-28;109(0):1-22.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  6. KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF
    Authors: C Bernhardt, E Sock, F Fröb, S Hillgärtne, M Nemer, M Wegner
    Nucleic Acids Research, 2022-11-11;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  7. Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice
    Authors: Y Zhao, W Zhu, T Wan, X Zhang, Y Li, Z Huang, P Xu, K Huang, R Ye, Y Xie, X Liu
    Nature Communications, 2022-11-10;13(1):6813.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  8. Phloretin enhances remyelination by stimulating oligodendrocyte precursor cell differentiation
    Authors: T Dierckx, S Vanherle, M Haidar, E Grajchen, F Mingneau, P Gervois, E Wolfs, D Bylemans, A Voet, T Nguyen, I Hamad, M Kleinewiet, JFJ Bogie, JJA Hendriks
    Proceedings of the National Academy of Sciences of the United States of America, 2022-11-07;119(46):e2120393119.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  9. Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death
    Authors: ER Aber, CJ Griffey, T Davies, AM Li, YJ Yang, KR Croce, JE Goldman, J Grutzendle, JC Canman, A Yamamoto
    Cell Reports, 2022-10-18;41(3):111480.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: ICC, IHC, Western Blot
  10. The alarmin interleukin-1? triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury
    Authors: Bretheau F, Castellanos-Molina A, B�langer D et al.
    Nature Communications
  11. The Neural Multilineage Differentiation Capacity of Human Neural Precursors from the Umbilical Cord-Ready to Bench for Clinical Trials
    Authors: D de Souza D, PEF Stricker, NB de Oliveir, BF Mogharbel, NN da Rosa, DSM Dziedzic, AC Irioda, K Athayde Te
    Membranes, 2022-09-09;12(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  12. MicroRNA-21-5p agomir inhibits apoptosis of oligodendrocyte precursor cell and attenuates white matter injury in neonatal rats
    Authors: F Zhang, Z Gou, Y Zhou, L Huang, C Shao, M Wang, C Wu, L Lu
    Brain research bulletin, 2022-08-17;0(0):.
    Species: Rat
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  13. Protocols for the Evaluation of Neurodevelopmental Alterations in Rabbit Models In Vitro and In Vivo
    Authors: Pla L, K�hne BA, Guardia-Escote L et al.
    Frontiers in Toxicology
  14. Establishment of mouse model of inherited PIGO deficiency and therapeutic potential of AAV-based gene therapy
    Authors: R Kuwayama, K Suzuki, J Nakamura, E Aizawa, Y Yoshioka, M Ikawa, S Nabatame, KI Inoue, Y Shimmyo, K Ozono, T Kinoshita, Y Murakami
    Nature Communications, 2022-06-03;13(1):3107.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  15. Docosahexaenoic Acid and Melatonin Prevent Impaired Oligodendrogenesis Induced by Intrauterine Growth Restriction (IUGR)
    Authors: BA Kühne, P Vázquez-Ar, M Fuentes-Am, L Pla, C Loreiro, J Gómez-Cata, E Gratacós, M Illa, M Barenys
    Biomedicines, 2022-05-23;10(5):.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: ICC
  16. Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination
    Authors: S Ghorbani, E Jelinek, R Jain, B Buehner, C Li, BM Lozinski, S Sarkar, DK Kaushik, Y Dong, TN Wight, S Karimi-Abd, GJ Schenk, EM Strijbis, J Geurts, P Zhang, CC Ling, VW Yong
    Nature Communications, 2022-05-04;13(1):2445.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  17. Ion Channel Drugs Suppress Cancer Phenotype in NG108-15 and U87 Cells: Toward Novel Electroceuticals for Glioblastoma
    Authors: J Mathews, F Kuchling, D Baez-Nieto, M Diberardin, JQ Pan, M Levin
    Cancers, 2022-03-15;14(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  18. Human neural cell type-specific�extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain
    Authors: You Y, Muraoka S, Jedrychowski MP et al.
    Journal of Extracellular Vesicles
  19. Enrichment of Glial Cells From Human Post-mortem Tissue for Transcriptome and Proteome Analysis Using Immunopanning
    Authors: A Nolle, I van Dijken, CM Waelti, D Calini, J Bryois, E Lezan, S Golling, A Augustin, L Foo, JJM Hoozemans
    Frontiers in Cellular Neuroscience, 2021-12-13;15(0):772011.
    Species: Human
    Sample Types: Whole Cells
    Applications: Immunopanning
  20. A Novel Vitronectin Peptide Facilitates Differentiation of Oligodendrocytes from Human Pluripotent Stem Cells (Synthetic ECM for Oligodendrocyte Differentiation)
    Authors: WU Park, GB Yeon, MS Yu, HG Goo, SH Hwang, D Na, DS Kim
    Biology, 2021-12-01;10(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry, ICC
  21. Human IPSC-Derived Model to Study Myelin Disruption
    Authors: M Chesnut, H Paschoud, C Repond, L Smirnova, T Hartung, MG Zurich, HT Hogberg, D Pamies
    International Journal of Molecular Sciences, 2021-08-31;22(17):.
    Species: Human
    Sample Types: Spheroid
    Applications: ICC
  22. Tension Sensor Based on Fluorescence Resonance Energy Transfer Reveals Fiber Diameter-Dependent Mechanical Factors During Myelination
    Authors: T Shimizu, H Murakoshi, H Matsumoto, K Ichino, A Hattori, S Ueno, A Ishida, N Tajiri, H Hida
    Frontiers in Cellular Neuroscience, 2021-08-02;15(0):685044.
    Species: Rat
    Sample Types: Whole Cells
    Applications: IHC
  23. Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence
    Authors: A Manousi, P Göttle, L Reiche, QL Cui, LM Healy, R Akkermann, J Gruchot, J Schira-Hei, JP Antel, HP Hartung, P Küry
    EBioMedicine, 2021-03-10;65(0):103276.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  24. Optic nerve regeneration screen identifies multiple genes restricting adult neural repair
    Authors: JA Lindborg, NM Tran, DM Chenette, K DeLuca, Y Foli, R Kannan, Y Sekine, X Wang, M Wollan, IJ Kim, JR Sanes, SM Strittmatt
    Cell Reports, 2021-03-02;34(9):108777.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  25. BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes
    Authors: M Yazdankhah, S Ghosh, P Shang, N Stepicheva, S Hose, H Liu, X Chamling, S Tian, MLG Sullivan, MJ Calderon, CS Fitting, J Weiss, A Jayagopal, JT Handa, JA Sahel, JS Zigler, PR Kinchingto, DJ Zack, D Sinha
    Autophagy, 2021-01-19;0(0):1-20.
    Species: Rat
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  26. Umbilical artery tissue contains p75 neurotrophin receptor-positive pericyte-like cells that possess neurosphere formation capacity and neurogenic differentiation potential
    Authors: R Fujii-Tezu, M Ishige-Wad, N Nagoshi, H Okano, H Mugishima, S Takahashi, I Morioka, T Matsumoto
    Regenerative Therapy, 2020-12-24;16(0):1-11.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  27. Hypoxia-inducible factor-2&alpha is crucial for proper brain development
    Authors: K Kleszka, T Leu, T Quinting, H Jastrow, S Pechlivani, J Fandrey, T Schreiber
    Sci Rep, 2020-11-05;10(1):19146.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  28. Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells
    Authors: JA García-Leó, B García-Día, K Eggermont, L Cáceres-Pa, K Neyrinck, R Madeiro da, JC Dávila, A Baron-Van, A Gutiérrez, CM Verfaillie
    Nat Protoc, 2020-10-23;15(11):3716-3744.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  29. Lipid-specific IgMs induce antiviral responses in the CNS: implications for progressive multifocal leukoencephalopathy in multiple sclerosis
    Authors: L Hayden, T Semenoff, V Schultz, SF Merz, KJ Chapple, M Rodriguez, AE Warrington, X Shi, CS McKimmie, JM Edgar, K Thümmler, C Linington, M Pingen
    Acta Neuropathol Commun, 2020-08-13;8(1):135.
    Species: Mouse, Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  30. Susceptibility to erastin-induced ferroptosis decreases during maturation in a human oligodendrocyte cell line
    Authors: T Hoshino, H Yamakado, R Takahashi, SI Matsuzawa
    FEBS Open Bio, 2020-07-30;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  31. Isolation and characterization of neural crest-like progenitor cells in human umbilical cord blood
    Authors: Z Al-Bakri, M Ishige-Wad, N Fukuda, C Yoshida-No, N Nagoshi, H Okano, H Mugishima, T Matsumoto
    Regenerative Therapy, 2020-07-18;15(0):53-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  32. Effects of Biotin on survival, ensheathment, and ATP production by oligodendrocyte lineage cells in vitro
    Authors: QL Cui, YH Lin, YKT Xu, MGF Fernandes, VTS Rao, TE Kennedy, J Antel
    PLoS ONE, 2020-05-29;15(5):e0233859.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  33. Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation
    Authors: M Wedel, F Fröb, O Elsesser, MT Wittmann, DC Lie, A Reis, M Wegner
    Nucleic Acids Res., 2020-05-21;48(9):4839-4857.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  34. Variation of Human Neural Stem Cells Generating Organizer States In�Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates
    Authors: N Micali, SK Kim, M Diaz-Busta, G Stein-O'Br, S Seo, JH Shin, BG Rash, S Ma, Y Wang, NA Olivares, JI Arellano, KR Maynard, EJ Fertig, AJ Cross, RW Bürli, NJ Brandon, DR Weinberger, JG Chenoweth, DJ Hoeppner, N Sestan, P Rakic, C Colantuoni, RD McKay
    Cell Rep, 2020-05-05;31(5):107599.
    Species: Human
    Sample Types:
    Applications: IF
  35. Neural stem cell phenotype of tanycyte-like ependymal cells in the circumventricular organs and central canal of adult mouse brain
    Authors: E Furube, H Ishii, Y Nambu, E Kurganov, S Nagaoka, M Morita, S Miyata
    Sci Rep, 2020-02-18;10(1):2826.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  36. Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential
    Authors: K Thümmler, E Rom, T Zeis, M Lindner, S Brunner, JJ Cole, D Arseni, S Mücklisch, JM Edgar, N Schaeren-W, A Yayon, C Linington
    Acta Neuropathol Commun, 2019-12-19;7(1):212.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  37. MS CD49d+CD154+ Lymphocytes Reprogram Oligodendrocytes into Immune Reactive Cells Affecting CNS Regeneration
    Authors: P Piatek, M Namiecinsk, M Domowicz, P Przygodzka, M Wieczorek, S Michlewska, N Lewkowicz, M Tarkowski, P Lewkowicz
    Cells, 2019-11-25;8(12):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture, ICC
  38. Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells
    Authors: B Neumann, R Baror, C Zhao, M Segel, S Dietmann, KS Rawji, S Foerster, CR McClain, K Chalut, P van Wijnga, RJM Franklin
    Cell Stem Cell, 2019-10-03;25(4):473-485.e8.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  39. Induction of regional chemokine expression in response to human umbilical cord blood cell infusion in the neonatal mouse ischemia-reperfusion brain injury model
    Authors: N Baba, F Wang, M Iizuka, Y Shen, T Yamashita, K Takaishi, E Tsuru, S Matsushima, M Miyamura, M Fujieda, M Tsuda, Y Sagara, N Maeda
    PLoS ONE, 2019-09-04;14(9):e0221111.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  40. SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke
    Authors: JD Bernstock, L Peruzzotti, T Leonardi, N Vicario, D Ye, YJ Lee, D Maric, KR Johnson, Y Mou, A Van Den Bo, M Winterbone, GK Friedman, RJM Franklin, JM Hallenbeck, S Pluchino
    EBioMedicine, 2019-03-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  41. Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures
    Authors: RM Marton, Y Miura, SA Sloan, Q Li, O Revah, RJ Levy, JR Huguenard, SP Pa?ca
    Nat. Neurosci., 2019-01-28;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  42. N-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination
    Authors: X Yu, G Cheng, L Zhang, Y Zhang, Q Wang, M Zhao, L Zeng, Y Hu, L Feng
    Sci Rep, 2018-09-19;8(1):14040.
    Species: Rat
    Sample Types: Whole Cells
    Applications: IHC
  43. Chronic Electrical Stimulation Promotes the Excitability and Plasticity of ESC-derived Neurons following Glutamate-induced Inhibition In vitro
    Authors: CV Latchouman, L Jackson, MSE Sendi, KF Tehrani, LJ Mortensen, SL Stice, M Ghovanloo, L Karumbaiah
    Sci Rep, 2018-07-19;8(1):10957.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  44. INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice
    Authors: O Le, L Palacio, G Bernier, I Batinic-Ha, G Hickson, C Beauséjour
    Stem Cell Reports, 2018-04-26;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  45. Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes
    Authors: CP Yang, X Li, Y Wu, Q Shen, Y Zeng, Q Xiong, M Wei, C Chen, J Liu, Y Huo, K Li, G Xue, YG Yao, C Zhang, M Li, Y Chen, XJ Luo
    Nat Commun, 2018-02-26;9(1):838.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  46. Vitamin C promotes oligodendrocytes generation and remyelination
    Authors: YE Guo, N Suo, X Cui, Q Yuan, X Xie
    Glia, 2018-02-09;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  47. Erythropoietin signaling increases neurogenesis and oligodendrogenesis of endogenous neural stem cells following spinal cord injury both in�vivo and in�vitro
    Authors: H Zhang, X Fang, D Huang, Q Luo, M Zheng, K Wang, L Cao, Z Yin
    Mol Med Rep, 2017-10-25;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  48. Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain
    Authors: A Voronova, SA Yuzwa, BS Wang, S Zahr, C Syal, J Wang, DR Kaplan, FD Miller
    Neuron, 2017-05-03;94(3):500-516.e9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  49. Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency
    Authors: JH Lee, S Laronde, TJ Collins, Z Shapovalov, B Tanasijevi, JD McNicol, A Fiebig-Com, YD Benoit, JB Lee, RR Mitchell, M Bhatia
    Cell Rep, 2017-04-04;19(1):20-35.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry, ICC
  50. BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action
    Authors: K Dach, F Bendt, U Huebenthal, S Giersiefer, PJ Lein, H Heuer, E Fritsche
    Sci Rep, 2017-03-20;7(0):44861.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: ICC
  51. Unique spectral signatures of the nucleic acid dye acridine orange can distinguish cell death by apoptosis and necroptosis
    Authors: JR Plemel, AV Caprariell, MB Keough, TJ Henry, S Tsutsui, TH Chu, GJ Schenk, R Klaver, VW Yong, PK Stys
    J. Cell Biol, 2017-03-06;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  52. Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells
    Authors: T Yamashita, Y Miyamoto, Y Bando, T Ono, S Kobayashi, A Doi, T Araki, Y Kato, T Shirakawa, Y Suzuki, J Yamauchi, S Yoshida, N Sato
    PLoS ONE, 2017-02-13;12(2):e0171947.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  53. Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts
    Authors: L Leiss, E Mutlu, A Øyan, T Yan, O Tsinkalovs, L Sleire, K Petersen, MA Rahman, M Johannesse, SS Mitra, HK Jacobsen, KM Talasila, H Miletic, I Jonassen, X Li, NH Brons, KH Kalland, J Wang, PØ Enger
    BMC Cancer, 2017-02-07;17(1):108.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  54. Modulated DISP3/PTCHD2 expression influences neural stem cell fate decisions
    Authors: J Kon¡?ov , J Oltov , A Corlett, J Kopyci?ska, M Kol ?, P Bart?n?k, M Z¡kov 
    Sci Rep, 2017-01-30;7(0):41597.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  55. Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis
    Sci Rep, 2016-12-01;6(0):38108.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  56. Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica
    J Neuroinflammation, 2016-12-01;13(1):301.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-P
  57. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation
    Nat. Genet., 2016-11-14;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  58. Myelin Basic Protein Regulates Primitive and Definitive Neural Stem Cell Proliferation from the Adult Spinal Cord
    Stem Cells, 2016-09-23;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  59. Protein-Induced Pluripotent Stem Cells Ameliorate Cognitive Dysfunction and Reduce A? Deposition in a Mouse Model of Alzheimer's Disease
    Authors: MY Cha, YW Kwon, HS Ahn, H Jeong, YY Lee, M Moon, SH Baik, DK Kim, H Song, EC Yi, D Hwang, HS Kim, I Mook-Jung
    Stem Cells Transl Med, 2016-08-15;6(1):293-305.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  60. Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner.
    Authors: Arulmoli J, Pathak M, McDonnell L, Nourse J, Tombola F, Earthman J, Flanagan L
    Sci Rep, 2015-02-17;5(0):8499.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  61. Differentiation of human umbilical cord matrix mesenchymal stem cells into neural-like progenitor cells and maturation into an oligodendroglial-like lineage.
    Authors: Leite C, Silva N, Mendes S, Ribeiro A, de Faria J, Lourenco T, dos Santos F, Andrade P, Cardoso C, Vieira M, Paiva A, da Silva C, Cabral J, Relvas J, Graos M
    PLoS ONE, 2014-10-30;9(10):e111059.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC-Fr
  62. Activated CD8+ T lymphocytes inhibit neural stem/progenitor cell proliferation: role of interferon-gamma.
    Authors: Hu S, Rotschafer J, Lokensgard J, Cheeran M
    PLoS ONE, 2014-08-18;9(8):e105219.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  63. Molecular evidence for OCT4-induced plasticity in adult human fibroblasts required for direct cell fate conversion to lineage specific progenitors.
    Authors: Mitchell R, Szabo E, Shapovalova Z, Aslostovar L, Makondo K, Bhatia M
    Stem Cells, 2014-08-01;32(8):2178-87.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  64. TLR9 is critical for glioma stem cell maintenance and targeting.
    Authors: Herrmann A, Cherryholmes G, Schroeder A, Phallen J, Alizadeh D, Xin H, Wang T, Lee H, Lahtz C, Swiderski P, Armstrong B, Kowolik C, Gallia G, Lim M, Brown C, Badie B, Forman S, Kortylewski M, Jove R, Yu H
    Cancer Res, 2014-07-21;74(18):5218-28.
    Species: Human, Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, ICC, IHC
  65. Fluorescent protein-expressing neural progenitor cells as a tool for transplantation studies.
    Authors: Skardelly M, Hempel E, Hirrlinger J, Wegner F, Meixensberger J, Milosevic J
    PLoS ONE, 2014-06-16;9(6):e99819.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  66. Derivation of neural stem cells from human adult peripheral CD34+ cells for an autologous model of neuroinflammation.
    Authors: Wang, Tongguan, Choi, Elliot, Monaco, Maria Ch, Campanac, Emilie, Medynets, Marie, Do, Thao, Rao, Prashant, Johnson, Kory R, Elkahloun, Abdel G, Von Geldern, Gloria, Johnson, Tory, Subramaniam, Sriram, Hoffman, Dax, Major, Eugene, Nath, Avindra
    PLoS ONE, 2013-11-26;8(11):e81720.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  67. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway.
    Authors: Guo, Huang, Zhao, Zhen, Yang, Qi, Wang, Min, Bell, Robert D, Wang, Su, Chow, Nienwen, Davis, Thomas P, Griffin, John H, Goldman, Steven A, Zlokovic, Berislav
    J Neurosci, 2013-04-03;33(14):6181-90.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  68. Combining adult stem cells and olfactory ensheathing cells: the secretome effect.
    Authors: Silva N, Gimble J, Sousa N, Reis R, Salgado A
    Stem Cells Dev, 2013-01-14;22(8):1232-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  69. Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage.
    Authors: Yamaguchi Y, Shao Z, Sharif S, Du X, Myles T, Merchant M, Harsh G, Glantz M, Recht L, Morser J, Leung L
    J Biol Chem, 2012-11-30;288(5):3097-111.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  70. Curcumin protects pre-oligodendrocytes from activated microglia in vitro and in vivo.
    Authors: He LF, Chen HJ, Qian LH, Chen GY, Buzby JS
    Brain Res., 2010-04-24;1339(0):60-9.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  71. Extracellular magnesium enhances the damage to locomotor networks produced by metabolic perturbation mimicking spinal injury in the neonatal rat spinal cord in vitro.
    Authors: Margaryan G, Mladinic M, Mattioli C, Nistri A
    Neuroscience, 2009-07-07;163(2):669-82.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  72. Endogenous hepatocyte growth factor is a niche signal for subventricular zone neural stem cell amplification and self-renewal.
    Authors: Nicoleau C, Benzakour O, Agasse F, Thiriet N, Petit J, Prestoz L, Roger M, Jaber M, Coronas V
    Stem Cells, 2009-02-01;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  73. Autophagic death of adult hippocampal neural stem cells following insulin withdrawal.
    Authors: Yu SW, Baek SH, Brennan RT, Bradley CJ, Park SK, Lee YS, Jun EJ, Lookingland KJ, Kim EK, Lee H, Goudreau JL, Kim SW
    Stem Cells, 2008-07-24;26(10):2602-10.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  74. Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture.
    Authors: Sun Y, Pollard S, Conti L, Toselli M, Biella G, Parkin G, Willatt L, Falk A, Cattaneo E, Smith A
    Mol. Cell. Neurosci., 2008-03-18;38(2):245-58.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  75. Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development.
    Authors: Galabova-Kovacs G, Catalanotti F, Matzen D, Reyes GX, Zezula J, Herbst R, Silva A, Walter I, Baccarini M
    J. Cell Biol., 2008-03-10;180(5):947-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  76. Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells.
    Authors: Ruau D, Ensenat-Waser R, Dinger TC, Vallabhapurapu DS, Rolletschek A, Hacker C, Hieronymus T, Wobus AM, Muller AM, Zenke M
    Stem Cells, 2008-01-17;26(4):920-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  77. Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons.
    Authors: Hong S, Kang UJ, Isacson O, Kim KS
    J. Neurochem., 2007-10-18;104(2):316-24.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  78. Functional analysis of various promoters in lentiviral vectors at different stages of in vitro differentiation of mouse embryonic stem cells.
    Authors: Hong S, Hwang DY, Yoon S, Isacson O, Ramezani A, Hawley RG, Kim KS
    Mol. Ther., 2007-07-03;15(9):1630-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  79. Bcl-XL/Bax proteins direct the fate of embryonic cortical precursor cells.
    Authors: Chang MY, Sun W, Ochiai W, Nakashima K, Kim SY, Park CH, Kang JS, Shim JW, Jo AY, Kang CS, Lee YS, Kim JS, Lee SH
    Mol. Cell. Biol., 2007-04-16;27(12):4293-305.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-Fr
  80. Bone morphogenetic protein-mediated modulation of lineage diversification during neural differentiation of embryonic stem cells.
    Authors: Gossrau G, Thiele J, Konang R, Schmandt T, Brustle O
    Stem Cells, 2007-01-11;25(4):939-49.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  81. Isolation of an adult blood-derived progenitor cell population capable of differentiation into angiogenic, myocardial and neural lineages.
    Authors: Porat Y, Porozov S, Belkin D, Shimoni D, Fisher Y, Belleli A, Czeiger D, Silverman WF, Belkin M, Battler A, Fulga V, Savion N
    Br. J. Haematol., 2006-12-01;135(5):703-14.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  82. Neural conversion of human embryonic stem cell colonies in the presence of fibroblast growth factor-2.
    Authors: Benzing C, Segschneider M, Leinhaas A, Itskovitz-Eldor J, Brustle O
    Neuroreport, 2006-11-06;17(16):1675-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  83. Efficient induction of oligodendrocytes from human embryonic stem cells.
    Authors: Kang SM, Cho MS, Seo H, Yoon CJ, Oh SK, Choi YM, Kim DW
    Stem Cells, 2006-10-19;25(2):419-24.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  84. Increased myelinating capacity of embryonic stem cell derived oligodendrocyte precursors after treatment by interleukin-6/soluble interleukin-6 receptor fusion protein.
    Authors: Zhang PL, Izrael M, Ainbinder E, Ben-Simchon L, Chebath J, Revel M
    Mol. Cell. Neurosci., 2005-12-01;31(3):387-98.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  85. High-level expression of functional chemokine receptor CXCR4 on human neural precursor cells.
    Authors: Ni HT, Hu S, Sheng WS, Olson JM, Cheeran MC, Chan AS, Lokensgard JR, Peterson PK
    Brain Res. Dev. Brain Res., 2004-09-17;152(2):159-69.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  86. Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal.
    Authors: Tsai HH, Tessier-Lavigne M, Miller RH
    Development, 2003-05-01;130(10):2095-105.
    Species: Chicken, Rat
    Sample Types: Whole Cells
    Applications: ICC

FAQs

  1. What is the immunogen of Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Antibody, Catalog # MAB1326?

    • The immunogen of Catalog # MAB1326 is bovine brain corpus callosum white matter. It is a natural source of Oligodendrocyte Marker O4, not a recombinant protein or synthetic peptide. 

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Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Antibody
By Anonymous on 12/06/2021
Application: ICC/IF Sample Tested: Glial cells Species: Mouse
Immunocytochemistry/Immunofluorescence Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Antibody MAB1326
Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Antibody
By Davide Marangon on 07/16/2019
Application: ICC Sample Tested: Oligodendrocytes Species: Rat

ICC without detergents

Immunocytochemistry Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Antibody MAB1326
Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Antibody
By Marco Luciani on 04/16/2019
Application: ICC/IF Sample Tested: Adult brain Species: Mouse
Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Antibody
By Anonymous on 01/25/2018
Application: ICC/IF Sample Tested: IPS2 induced pluripotent stem cells Species: Mouse
Immunocytochemistry/Immunofluorescence Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Antibody MAB1326
Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Antibody
By Anonymous on 12/15/2016
Application: ICC/IF Sample Tested: Neural progenitor cells Species: Mouse

Our research focuses on how neural stem cells make the choice to differentiate into the various adult lineages such as neurons, astrocytes, and oligodendrocytes. We utilize the O4 oligodendrocyte marker as a tool to label differentiated oligodendrocytes and assess oligogenesis in various microenvironments.