Human/Mouse SDPR Antibody

Catalog #: AF5759
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
AF5759
AF5759-SP

Detection of Human and Mouse SDPR by Western Blot.

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Citations (2)

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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse SDPR Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human and mouse SDPR in Western blots.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human SDPR Gly2-Val180 Accession # O95810

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Purity

Immunogen affinity purified

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot

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Detection of Human and Mouse SDPR by Western Blot. Western blot shows lysates of human heart and mouse lung tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse SDPR Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5759) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for SDPR at approximately 70 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.

Background: SDPR

SDPR (Serum deprivation response gene; also SDR and PS-p68) is a 68-70 kDa member of the PTRF/SDPR family of proteins. It is expressed in striated muscle, platelets, and fibroblasts, and is cytosolic in location. SDPR is known to bind phosphatidylserine and form complexes with both PKC alpha and PTRF, targeting them to caveolae. Human SDPR is 425 amino acids (aa) in length. It contains an N-terminal acetylglycine, three coiled-coil regions (aa 61-82, 125-154, and 210-268), and two serine phosphorylation sites at positions 287 and 293. Over aa 1-180, human SDPR shares 91% aa identity with mouse SDPR.

Long Name

Serum Deprivation Response [Phosphatidylserine Binding Protein]

Entrez Gene IDs

8436 (Human); 20324 (Mouse); 316384 (Rat)

Alternate Names

cavin-2; Phosphatidylserine-binding protein; PS-p68; PS-p68serum deprivation response (phosphatidylserine-binding protein); SDPR; SDR; SDRphosphatidylserine binding protein; serum deprivation response (phosphatidylserine binding protein); serum deprivation response; serum deprivation-response protein

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human/Mouse SDPR Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination
Authors: E Seemann, M Sun, S Krueger, J Tröger, W Hou, N Haag, S Schüler, M Westermann, CA Huebner, B Romeike, MM Kessels, B Qualmann
Elife, 2017-12-05;6(0):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot
Rosiglitazone drives cavin-2/SDPR expression in adipocytes in a CEBP?-dependent manner
Authors: B Hansson, C Rippe, D Kotowska, S Wasserstro, J Säll, O Göransson, K Swärd, KG Stenkula
PLoS ONE, 2017-03-09;12(3):e0173412.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot