Human Neurogenin-1 Antibody

Catalog #: MAB3524 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB3524
MAB3524-SP

All Neurogenin-1 Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Neurogenin-1 Antibody Summary

Species Reactivity

Human

Specificity

Detects human Neurogenin-1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human Neurogenin-3 is observed.

Source

Monoclonal Mouse IgG₁ Clone # 309707

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

E. coli-derived recombinant human Neurogenin‑1
Ala145-His237
Accession # NP_006152

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Purity

Protein A or G purified from hybridoma culture supernatant

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human Neurogenin‑1

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Neurogenin-1

Neurogenin-1 is a 26 kDa developmentally expressed nuclear protein of the basic helix-loop-helix (bHLH) family, class B subfamily. bHLH proteins are transcription factors that form dimers to bind DNA. NGN1 is expressed only in embryonic neural tissue and supports neuronal differentiation but inhibits glial cell differentiation. Human Neurogenin-1 shows 93% amino acid identity with both mouse and rat Neurogenin-1 over the sequence used as an immunogen.

Entrez Gene IDs

4762 (Human); 18014 (Mouse)

Alternate Names

AKA; BHLHA6; bHLHa6NGN-1; Class A basic helix-loop-helix protein 6; Math4C; NEUROD3; NEUROD3neurogenic differentiation 3; NEUROG1; Neurogenic basic-helix-loop-helix protein; Neurogenic differentiation factor 3; neurogenin 1; Neurogenin1; Neurogenin-1; NGN; ngn1