Human OAS2 Antibody

Name: Human OAS2 Antibody
Brand: R&D Systems
SKU: MAB1925
Rating: 5 (1 reviews)

Catalog #: MAB1925
1 Citation 1 Review Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB1925
MAB1925-SP

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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human OAS2 Antibody Summary

Species Reactivity

Human

Specificity

Detects human OAS2.

Source

Monoclonal Mouse IgG_2A Clone # HLS56/3

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

2’,5’-Oligoadenylate Synthetase-2

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Immunoprecipitation

Hovanessian, A.G. et al. (1987) EMBO J. 6:1273.

Immunocytochemistry

3-25 µg/mL

Immersion fixed U266 human myeloma cell line

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunocytochemistry

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OAS2 in U266 Human Cell Line. OAS2 was detected in immersion fixed U266 human myeloma cell line using Mouse Anti-Human OAS2 Monoclonal Antibody (Catalog # MAB1925) at 3 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. Staining was performed using our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: OAS2

OAS2, also known as OAS (69 kDa), is one of three related proteins (along with OAS1 and OAS3) that catalyze the conversion of ATP into 2’,5’-linked adenosine oligomers with the general formula pppA(2’,5’A)_n where n > 1 (2, 3) These proteins are induced by interferons, activated by double-stranded RNA, and are implicated in anti-viral immunity (1, 4, 5).

References

Hovanessian, A.G. et al. (1987) EMBO J. 6:1273.
Hovanessian, A.G. et al. (1977) Nature 268:537.
Kerr, I.M. and R.E. Brown (1978) Proc. Natl. Acad. Sci. USA 75:256.
Hovanessian, A.G. et al. (1988) J. Biol. Chem. 263:4959.
Marie, I. et al. (1990) J. Interferon Res. 10:571.
Marie, I. et al. (1990) J. Biol. Chem. 265:18601.

Long Name

2’,5’-Oligoadenylate Synthetase-2

Entrez Gene IDs

4939 (Human)

Alternate Names

(2-5')oligo(A) synthase 2; (2'-5')oligo(A) synthetase 2; (2-5')oligo(A) synthetase 2; 2'5' oligoadenylate synthetase 2; 2-5A synthase 2; 2-5A synthetase 2; 2'-5'-oligoadenylate synthase 2; 2'-5'-oligoadenylate synthetase 2 (69-71 kD); 2'-5'-oligoadenylate synthetase 2, 69/71kDa; EC 2.7.7; EC 2.7.7.-; MGC78578; OAS2; p69 OAS / p71 OAS; p69OAS / p71OAS

Product Datasheets

Product Datasheet

COA

SDS

Citation for Human OAS2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1