Human PDGF R beta PE-conjugated Antibody Summary
Detects the PDGF R beta -subunit of human and primate species (monkey and baboon) but not the rat or mouse receptors. Its ability to bind to receptors from other species has not been tested.
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
View Larger
Detection of PDGF R beta in MG‑63 Human Cell Line by Flow Cytometry. MG-63 human osteosarcoma cell line was stained with Mouse Anti-Human PDGF R beta PE-conjugated Monoclonal Antibody (Catalog # FAB1263P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: PDGF R beta
PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA, PDGF‑BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF R alpha binds all three PDGF isoforms with high affinity, PDGF R beta binds PDGF-BB only with high-affinity. Both PDGF R alpha and PDGF R beta are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, SCF and Flt-3 Ligand. All class III RTKs are characterized by the presence of five immunoglobulin‑like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo- and hetero‑dimerization and signal transduction. The expression of the alpha and beta receptors is independently regulated in various cell types. Recombinant soluble PDGF R beta binds PDGF with high affinity and is a potent PDGF antagonist (4).
- Hart et al. (1987) J. Biol. Chem. 262:10780.
- Gronwald et al. (1988) Proc. Natl. Acad. Sci. 85:3435.
- Seifert et al. (1989) J. Biol. Chem. 264:8771.
- Heldin, C.H. and L. Claesson-Welsh (1994) in Guidebook to Cytokines and Their Receptors, Nicola, N.A. ed. Oxford University Press, New York, p. 202.
Product Datasheets
Citations for Human PDGF R beta PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
9
Citations: Showing 1 - 9
Filter your results:
Filter by:
-
Transient and Prolonged Activation of Wnt Signaling Contribute Oppositely to the Pathogenesis of Asherman's Syndrome
Authors: X Xue, X Li, J Yao, X Zhang, X Ren, S Xu
International Journal of Molecular Sciences, 2022-08-08;23(15):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry, Neutralization -
Hypoxia Regulates the Self-Renewal of Endometrial Mesenchymal Stromal/Stem-like Cells via Notch Signaling
Authors: S Zhang, RWS Chan, EHY Ng, WSB Yeung
International Journal of Molecular Sciences, 2022-04-21;23(9):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry, Magnetic Bead Selection -
Spatial and temporal characterization of endometrial mesenchymal stem-like cells activity during the menstrual cycle
Authors: William S B Yeung
Exp. Cell Res., 2016-11-24;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Hypoxia-controlled EphA3 marks a human endometrium-derived multipotent mesenchymal stromal cell that supports vascular growth.
Authors: To C, Farnsworth R, Vail M, Chheang C, Gargett C, Murone C, Llerena C, Major A, Scott A, Janes P, Lackmann M
PLoS ONE, 2014-11-24;9(11):e112106.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Antiangiogenic cancer drug sunitinib exhibits unexpected proangiogenic effects on endothelial cells.
Authors: Norton, Kerri-An, Han, Zheyi, Popel, Aleksand, Pandey, Niranjan
Onco Targets Ther, 2014-09-09;7(0):1571-82.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-kappaB signaling pathway and proinflammatory response in human pericytes.
Authors: Guijarro-Munoz I, Compte M, Alvarez-Cienfuegos A, Alvarez-Vallina L, Sanz L
J Biol Chem, 2013-12-04;289(4):2457-68.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Bone marrow fibroblasts parallel multiple myeloma progression in patients and mice: in vitro and in vivo studies.
Authors: Frassanito M, Rao L, Moschetta M, Ria R, di Marzo L, De Luisi A, Racanelli V, Catacchio I, Berardi S, Basile A, Menu E, Ruggieri S, Nico B, Ribatti D, Fumarulo R, Dammacco F, Vanderkerken K, Vacca A
2013-09-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Cultivation and characterization of cornea limbal epithelial stem cells on lens capsule in animal material-free medium.
Authors: Albert R, Vereb Z, Csomos K, Moe M, Johnsen E, Olstad O, Nicolaissen B, Rajnavolgyi E, Fesus L, Berta A, Petrovski G
PLoS ONE, 2012-10-09;7(10):e47187.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis.
Authors: Guijarro-Munoz I, Cuesta AM, Alvarez-Cienfuegos A, Geng JG, Alvarez-Vallina L, Sanz L
Exp. Cell Res., 2011-12-14;318(4):371-8.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsReviews for Human PDGF R beta PE-conjugated Antibody
Average Rating: 5 (Based on 1 Review)
Have you used Human PDGF R beta PE-conjugated Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
