Human TACI/TNFRSF13B PE-conjugated Antibody
Human TACI/TNFRSF13B PE-conjugated Antibody Summary
Ser2-Thr166
Accession # O14836
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of TACI/TNFRSF13B in Human Peripheral Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human TACI/TNFRSF13B PE-conjugated Monoclonal Antibody (Catalog # FAB1741P) and Mouse Anti-Human CD19 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB4867F). Quadrant markers were set based on control antibody staining (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.
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Detection of TACI/TNFRSF13B in Raji Human Cell Line by Flow Cytometry. Raji human Burkitt's lymphoma cell line was stained with Mouse Anti-Human TACI/TNFRSF13B PE-conjugated Monoclonal Antibody (Catalog # FAB1741P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
Background: TACI/TNFRSF13B
TACI (Transmembrane Activator and CAML-Interactor) is a 30-32 kDa member of the TNF receptor superfamily. It is classified as is a type III membrane protein with an extracellular N‑terminus in the absence of a cleaved signal sequence. The extracellular region of TACI contains two cysteine rich domains. Within the TNFRSF, it shares the highest homology with BCMA. TACI and BCMA have both been shown to bind APRIL and BAFF, members of the TNF ligand superfamily. TACI is expressed on the cell surface of B cells and activated, but not resting, T cells. Analogous to BCMA, data suggests that TACI may play an important role in B cell development, function and regulation. Human TACI is a 293 amino acid (aa) protein consisting of a 166 aa extracellular domain, a 20 aa transmembrane domain, and a 107 aa intracellular domain. Human and mouse TACI share 54% amino acid identity.
Product Datasheets
Citations for Human TACI/TNFRSF13B PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 7
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Association of Common Variants of TNFSF13 and TNFRSF13B Genes with CLL Risk and Clinical Picture, as Well as Expression of Their Products-APRIL and TACI Molecules
Authors: M Jasek, A Bojarska-J, M Sobczy?ski, M Wagner, S Chocholska, J Roli?ski, D Wo?owiec, L Karabon
Cancers (Basel), 2020-10-06;12(10):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Correlation of APRIL with production of inflammatory cytokines during acute malaria in the Brazilian Amazon
Authors: RA Pinna, AC Dos Santos, DS Perce-da-S, LA da Silva, RNR da Silva, MR Alves, F Santos, J de Oliveir, JC Lima-Junio, DM Villa-Verd, PM De Luca, CE Carvalho-P, DM Banic
Immun Inflamm Dis, 2018-01-03;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Control of Viremia Enables Acquisition of Resting Memory B Cells with Age and Normalization of Activated B Cell Phenotypes in HIV-Infected Children.
Authors: Muema D, Macharia G, Hassan A, Mwaringa S, Fegan G, Berkley J, Nduati E, Urban B
J Immunol, 2015-06-26;195(3):1082-91.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity.
Authors: Hoffmann F, Kuhn P, Laurent S, Hauck S, Berer K, Wendlinger S, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister H, Alexander T, Hiepe F, Kumpfel T, Crawford H, Wekerle H, Hohlfeld R, Lichtenthaler S, Meinl E
J Immunol, 2014-12-10;194(2):542-52.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
BAFF and APRIL expression in B-cell chronic lymphocytic leukemia: correlation with biological and clinical features.
Authors: Bojarska-Junak A, Hus I, Chocholska S, Wasik-Szczepanek E, Sieklucka M, Dmoszynska A, Rolinski J
Leuk. Res., 2009-04-23;33(10):1319-27.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease.
Authors: Sarantopoulos S, Stevenson KE, Kim HT, Cutler CS, Bhuiya NS, Schowalter M, Ho VT, Alyea EP, Koreth J, Blazar BR, Soiffer RJ, Antin JH, Ritz J
Blood, 2009-01-23;113(16):3865-74.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment.
Authors: Tai YT, Li XF, Breitkreutz I, Song W, Neri P, Catley L, Podar K, Hideshima T, Chauhan D, Raje N, Schlossman R, Richardson P, Munshi NC, Anderson KC
Cancer Res., 2006-07-01;66(13):6675-82.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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