Human TLR7 PE-conjugated Antibody Summary
Met360-Leu516
Accession # Q9NYK1
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of TLR7 in Ramos Human Cell Line by Flow Cytometry. Ramos human Burkitt's lymphoma cell line was stained with Mouse Anti-Human TLR7 PE-conjugated Monoclonal Antibody (Catalog # IC5875P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TLR7
Toll-like receptor 7 (TLR7) is a 120 kDa (predicted, unglycosylated) type I transmembrane glycoprotein and member of the Toll-like receptor family. Human TLR7 is synthesized as a 1049 amino acid (aa) precursor that contains a 26 aa signal sequence, an 803 aa extracellular domain (ECD), a 21 aa transmembrane sequence, and a 189 aa cytoplasmic domain. Mature human TLR7 is 81% aa identical to mature mouse TLR7. TLR7 is detected in brain, placenta, spleen, stomach, small intestine, lung, and in plasmacytoid pre-dendritic cells. Functionally, TLR7 participates in the innate immune response to microbial agents.
Product Datasheets
Citations for Human TLR7 PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 6
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Monocyte-dependent co-stimulation of cytokine induction in human gammadelta T cells by TLR8 RNA ligands
Authors: R Serrano, C Coch, C Peters, G Hartmann, D Wesch, D Kabelitz
Scientific Reports, 2021-07-27;11(1):15231.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Peripheral blood and hepatic Toll-like receptor 7 expression and interferon lambda 1 levels in chronic hepatitis C: Relation to virus replication and liver injury
Authors: H El Aggan, N Farahat, N El Deeb, A Zeid, A El-Shendid
Microb. Pathog., 2019-03-26;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Expression of Toll-like receptor -7 and -9 in B cell subsets from patients with primary Sjogren's syndrome.
Authors: Karlsen M, Hansen T, Nordal H, Brun J, Jonsson R, Appel S
PLoS ONE, 2015-03-19;10(3):e0120383.
Species: Human
Sample Types: Whole Cells
Applications: IHC-Fr -
Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors.
Authors: Metcalf T, Cubas R, Ghneim K, Cartwright M, Grevenynghe J, Richner J, Olagnier D, Wilkinson P, Cameron M, Park B, Hiscott J, Diamond M, Wertheimer A, Nikolich-Zugich J, Haddad E
Aging Cell, 2015-02-27;14(3):421-32.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
A role for microRNA-155 modulation in the anti-HIV-1 effects of Toll-like receptor 3 stimulation in macrophages.
Authors: Swaminathan G, Rossi F, Sierra L, Gupta A, Navas-Martin S, Martin-Garcia J
PLoS Pathog, 2012-09-20;8(9):e1002937.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C virus infection.
Authors: Ma CJ, Ni L, Zhang Y, Zhang CL, Wu XY, Atia AN, Thayer P, Moorman JP, Yao ZQ
Immunology, 2010-11-23;132(3):421-31.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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