Human TRA-1-60(R) Neuraminidase Resistant Epitope Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB4770S Datasheet / COA / SDS

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FAB4770S-100UG

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Human TRA-1-60(R) Neuraminidase Resistant Epitope Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human TRA‑1‑60(R).

Source

Monoclonal Mouse IgM Clone # TRA-1-60

Immunogen

2102Ep human embryonal carcinoma cell line

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25-1 µg/10⁶ cells

BG01V human embryonic stem cells

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: TRA-1-60(R)

TRA-1-60 is a monoclonal antibody raised against a cell surface antigen of human embryonal carcinoma (EC) cells (1). The TRA-1-60 epitope is also found on human embryonic stem (ES) cells and primordial germ cells, and TRA-1-60 serves as a serum marker in patients with germ cell tumors (2‑4). Investigation into the identity of the TRA-1-60 epitope demonstrated that it is a carbohydrate carried by a cell surface, sialylated, keratan sulfate proteoglycan (5). Subsequent evidence implicated podocalyxin as a carrier for the TRA-1-60 epitope (6).

References

Andrews, P. et al. (1984) Hybridoma 3:347.
Thomson, J. et al. (1998) Science 282:1145.
Giwercman, A. et al. (1993) Cancer 72:1308.
Marrink, J. et al. (1991) Int. J. Cancer 49:368.
Badcock, G. et al. (1999) Cancer Res. 59:4715.
Schopperle, W. and W. DeWolf (2007) Stem Cells 25:723.

Long Name

Tumor-related Antigen-1-60 [R]

Entrez Gene IDs

5420 (Human)

Alternate Names

RA160; TRA160(R); TRA-1-60(R); tra61

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Product Specific Notices

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.