Human ULBP-3 PE-conjugated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of ULBP‑3 in PC-3 Human Cell Line by Flow Cytometry. PC-3 human prostate carcinoma cell line was stained with Mouse Anti-Human ULBP-3 PE-conjugated Monoclonal Antibody (Catalog # FAB1517P, filled histogram) or isotype control antibody (IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Detection of ULBP‑3 in Human monocyte-derived dendritic cells by Flow Cytometry. Human monocyte-derived dendritic cells were stained with Mouse Anti-Human ULBP-3 PE-conjugated Monoclonal Antibody (Catalog # FAB1517P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Detection of ULBP‑3 in BaF3 Mouse Cell Line Transfected with Human ULBP-3 by Flow Cytometry. BaF3 mouse pro-B cell line transfected with human ULBP-3 was stained with Mouse Anti-Human ULBP-3 PE-conjugated Monoclonal Antibody (Catalog # FAB1517P, filled histogram) or isotype control antibody (IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: ULBP-3
ULBP-3 is a member of a family of cell-surface proteins that function as ligands for human NKG2D. ULBP-3 has also been described under the names RaeT1N (retinoic acid early transcript), NKG2DL3, and ALCAN-gamma. The name ULBP-3 derives from the original identification of three proteins, ULBP-1, -2, and -3, as ligands for the human cytomegalovirus glycoprotein UL16; they were designated UL16 binding proteins (ULBP). The gene for ULBP-3 resides in a cluster of ten related genes, six of which encode potentially functional glycoproteins. Amino acid sequence identity within this family ranges from 30‑60%. These proteins are distantly related to MHC class I proteins, but they possess only the alpha 1 and alpha 2 Ig-like domains, and they have no capacity to bind peptide or interact with beta 2‑microglobulin. Some family members, including ULBP-3, are anchored to the membrane via a GPI-linkage, whereas others have transmembrane domains. ULBP-3 and several other family members are known to bind to human NKG2D, an activating receptor expressed on NK cells, NKT cells, gamma δ T cells, and CD8+ alpha beta T cells. Engagement of NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. The ULBPs are expressed on some tumor cells and have been implicated in tumor surveillance (1‑7).
- Cosman, D. et al. (2001) Immunity 14:123.
- Kubin, M. et al. (2001) Eur. J. Immunol. 31:1428.
- Sutherland, C. et al. (2002) J. Immunol. 168:671.
- Steinle, A. et al. (2001) Immunogenetics 53:279.
- Sutherland, C. et al. (2001) Immunol. Rev. 181:185.
- Pende, D. et al. (2002) Cancer Res. 62:6178.
- Radosavljevic, M. et al. (2002) Genomics 79:114.
- NKG2D and its Ligands (2002) http://www.RnDSystems.com/.
Product Datasheets
Citations for Human ULBP-3 PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Tinostamustine (EDO-S101), an Alkylating Deacetylase Inhibitor, Enhances the Efficacy of Daratumumab in Multiple Myeloma by Upregulation of CD38 and NKG2D Ligands
Authors: Díaz-Tejedor, A;Rodríguez-Ubreva, J;Ciudad, L;Lorenzo-Mohamed, M;González-Rodríguez, M;Castellanos, B;Sotolongo-Ravelo, J;San-Segundo, L;Corchete, LA;González-Méndez, L;Martín-Sánchez, M;Mateos, MV;Ocio, EM;Garayoa, M;Paíno, T;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Antitumor effects of NK cells expanded by activation pre?processing of autologous feeder cells before irradiation in colorectal cancer
Authors: Koh, EK;Lee, HR;Son, WC;Park, GY;Bae, J;Park, YS;
Oncology letters
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
gammadelta T cells are effectors of immunotherapy in cancers with HLA class I defects
Authors: NL de Vries, J van de Haa, V Veninga, M Chalabi, ME Ijsselstei, M van der Pl, J van den Bu, D Ruano, JG van den Be, JB Haanen, LJ Zeverijn, BS Geurts, GF de Wit, TW Battaglia, H Gelderblom, HMW Verheul, TN Schumacher, LFA Wessels, F Koning, NFCC de Miranda, EE Voest
Nature, 2023-01-11;613(7945):743-750.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
NKp44-based chimeric antigen receptor effectively redirects primary T cells against synovial sarcoma
Authors: Y Murayama, Y Kasahara, N Kubo, C Shin, M Imamura, N Oike, T Ariizumi, A Saitoh, M Baba, T Miyazaki, Y Suzuki, Y Ling, S Okuda, K Mihara, A Ogose, H Kawashima, C Imai
Translational Oncology, 2022-08-20;25(0):101521.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Genetic and Molecular Basis of Heterogeneous NK Cell Responses against Acute Leukemia
Authors: DR Makanga, F Da Rin de, G David, C Willem, L Dubreuil, N Legrand, T Guillaume, P Peterlin, A Lebourgeoi, MC Béné, A Garnier, P Chevallier, K Gendzekhad, A Cesbron, K Gagne, B Clemenceau, C Retière
Cancers (Basel), 2020-07-16;12(7):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity
Authors: D Suzuki, C Flahou, N Yoshikawa, I Stirblyte, Y Hayashi, A Sawaguchi, M Akasaka, S Nakamura, N Higashi, H Xu, T Matsumoto, K Fujio, MG Manz, A Hotta, H Takizawa, K Eto, N Sugimoto
Stem Cell Reports, 2019-12-26;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy
Authors: M Chollat-Na, T Ben Safta-, D Haferssas, G Meurice, S Chouaib, J Thiery
Cell Death Dis, 2019-09-20;10(10):695.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro
Authors: Y Tanaka, T Nakazawa, M Nakamura, F Nishimura, R Matsuda, K Omoto, Y Shida, T Murakami, I Nakagawa, Y Motoyama, H Morita, T Tsujimura, H Nakase
PLoS ONE, 2019-03-06;14(3):e0212455.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Expression of ligands for activating natural killer cell receptors on cell lines commonly used to assess natural killer cell function
Authors: A Tremblay-M, S Coenraads, Z Kiani, FP Dupuy, NF Bernard
BMC Immunol., 2019-01-29;20(1):8.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Mesenchymal stromal cells of the bone marrow and natural killer cells: cell interactions and cross modulation
Authors: M Najar, M Fayyad-Kaz, N Meuleman, D Bron, H Fayyad-Kaz, L Lagneaux
J Cell Commun Signal, 2018-01-19;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Expression Profiles of Ligands for Activating Natural Killer Cell Receptors on HIV Infected and Uninfected CD4? T Cells
Authors: A Tremblay-M, J Bruneau, B Lebouché, I Lisovsky, R Song, NF Bernard
Viruses, 2017-10-12;9(10):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Interleukin-15 stimulates natural killer cell-mediated killing of both human pancreatic cancer and stellate cells
Authors: JRM Van Audena, J De Waele, E Marcq, J Van Loenho, E Lion, JMJ Van den Be, R Jesenofsky, A Masamune, G Roeyen, P Pauwels, F Lardon, M Peeters, ELJ Smits
Oncotarget, 2017-01-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
T Cells Infiltrating Diseased Liver Express Ligands for the NKG2D Stress Surveillance System
Authors: Wei-Chen Huang
J. Immunol, 2016-12-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Combination treatment with decitabine and ionizing radiation enhances tumor cells susceptibility of T cells
Sci Rep, 2016-09-27;6(0):32470.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Decitabine enhances anti-CD33 monoclonal antibody BI 836858-mediated natural killer ADCC against AML blasts
Blood, 2016-03-24;127(23):2879-89.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Thermal- and Oxidative Stress Causes Enhanced Release of NKG2D Ligand-Bearing Immunosuppressive Exosomes in Leukemia/Lymphoma T and B Cells.
Authors: Hedlund M, Nagaeva O, Kargl D, Baranov V, Mincheva-Nilsson L
PLoS ONE, 2011-02-25;6(2):e16899.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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