Icilin
Chemical Name: 3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one
Purity: ≥98%
Biological Activity
Icilin is a cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures. Produces "wet shakes" in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Activation of host transient receptor potential (TRP) channels by praziquantel stereoisomers
GS Gunaratne, NA Yahya, PI Dosa, JS Marchant
PLoS Negl Trop Dis, 2018;12(4):e0006420. -
Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay.
Behrendt et al.
Br.J.Pharmacol., 2004;141:737 -
Identification of a cold receptor reveals a general role for TRP channels in thermosensation.
McKemy et al.
Nature, 2002;416:52 -
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.
Story et al.
Cell, 2003;112:819 -
AG-3-5: a chemical producing sensations of cold.
Wei et al.
J.Pharm.Pharmacol., 1983;35:110
Product Datasheets
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Citations for Icilin
The citations listed below are publications that use Tocris products. Selected citations for Icilin include:
5 Citations: Showing 1 - 5
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Structural insights into TRPM8 inhibition and desensitization.
Authors: Diver Et al.
Science 2019;365:1434
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Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets.
Authors: Ganley Et al.
Oncogene 2015;35:7626
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Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice.
Authors: Knowlton Et al.
PLoS One 2011;6:e25894
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PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression.
Authors: Gkika Et al.
Respir Res 2010;29:4611
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Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
Authors: Proudfoot Et al.
Curr Biol 2006;16:1591
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