Indomethacin
Chemical Name: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole
Purity: ≥99%
Biological Activity
Indomethacin is a cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Suppression of Canine Dendritic Cell Activation/Maturation and Inflammatory Cytokine Release by Mesenchymal Stem Cells Occurs Via Multiple Distinct Biochemical Pathways
Stem Cells Dev., 2016;0(0):. -
Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models.
Palomer et al.
J.Med.Chem., 2002;45:1402 -
Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool.
Walters and Willoughby
J.Pathol.Bacteriol., 1965;90:641 -
Chemical and biological studies on indomethacin, sul. and their analogs.
Shen and Winter
Adv.Drug Res., 1977;12:90 -
A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing.
Gordon et al.
Nature, 2020;
Product Datasheets
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Citations for Indomethacin
The citations listed below are publications that use Tocris products. Selected citations for Indomethacin include:
6 Citations: Showing 1 - 6
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DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation.
Authors: Allen Et al.
Front Oncol 2015;5:260
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Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity.
Authors: Gonnermann Et al.
Oncoimmunology 2015;4:e988460
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Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
Authors: Cramer Et al.
J Biomed Sci 2015;35:5664
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Lactate-mediated glia-neuronal signalling in the mammalian brain.
Authors: Tang Et al.
Nat Commun 2014;5:3284
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Multiscale prediction of patient-specific platelet function under flow.
Authors: Flamm Et al.
Blood 2012;120:190
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CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis.
Authors: Miller Et al.
Proc Natl Acad Sci U S A 2012;109:20602
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