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INF 4E

Catalog #: 6172 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6172/10
INF 4E | CAS No. 88039-46-7 | Inflammasomes Inhibitors
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Description: Caspase-1 and NLRP3 inflammasome inhibitor

Chemical Name: Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate

Purity: ≥98%

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Biological Activity

INF 4E is a NLRP3 inflammasome and caspase-1 inhibitor (Ki = 9.6 μM for caspase-1). Inhibits Nigericin (Cat. No. 4312) or ATP (Cat.No. 3245) induced pyroptosis of PMA-differentiated and LPS-primed THP-1 cells and activates the Keap1-Nrf2 pathway.

Technical Data

M.Wt:
240.68
Formula:
C12H13ClO3
Solubility:
Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
88039-46-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Electrophilic Warhead-Based Design of Compounds Preventing NLRP3 Inflammasome-Dependent Pyroptosis.
    Cocco M, Garella D, Di Stilo A et al.
    J Med Chem.

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