Isradipine
Chemical Name: 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester
Purity: ≥99%
Biological Activity
Isradipine is a potent and selective L-type voltage-gated Ca2+ channel blocker. EC50 and pA2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca2+-induced contractions of rabbit aorta respectively; EC25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo, exerting primary effects on vascular tissue with secondary negative chronotropic action.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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PN 200-110, a new calcium antagonist: electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta.
Hof et al.
J.Cardiovasc.Pharmacol., 1984;6:399 -
Separation of the coronary vasodilator from the cardiac effects of PN 200-110, a new dihydropyridine calcium antagonist, in the dog heart.
Wada et al.
J.Cardiovasc.Pharmacol., 1985;7:190 -
Pharmacology of the calcium antagonist israd.
Ruegg and Hof
Drugs, 1990;40:3
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Citations for Isradipine
The citations listed below are publications that use Tocris products. Selected citations for Isradipine include:
6 Citations: Showing 1 - 6
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An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
Authors: McKeithan Et al.
Front Physiol 2017;8:766
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Inflammation alters AMPA-stimulated calcium responses in dorsal striatal D2 but not D1 spiny projection neurons.
Authors: Winland Et al.
Eur J Neurosci 2017;46:2519
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Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology.
Authors: Pourbadie Et al.
J Neurosci 2015;10:e0117555
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Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra DA neurons.
Authors: Dragicevic Et al.
PLoS One 2014;137:2287
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A mammalian retinal bipolar cell uses both graded changes in membrane voltage and all-or-nothing Na+ spikes to encode light.
Authors: Saszik and DeVries
J Neurosci 2012;32:297
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Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
Authors: Murray Et al.
J Neurophysiol 2011;106:925
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