ITH 12575
Chemical Name: 7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one
Purity: ≥98%
Biological Activity
ITH 12575 is a mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor. Reduces Ca2+ efflux from the mitochondria to the cytosol in HeLa cells (EC50 = 0.69 μM). Protects against glutamate-induced excitotoxitiy in rat hippocampal slices and oligomycin A/rotenone induced oxidative stress in neuroblastoma cells in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Benzothiazepine CGP37157 analogues exert cytoprotection in various in vitro models of neurodegeneration.
Martínez-Sanz et al.
ACS Chem.Neurosci., 2015;6:1626 -
Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca2+ entry through CALHM1.
Moreno-Ortega et al.
Neuropharmacology, 2015;95:503
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