Home / Adenylyl Cyclase Inhibitors / KH 7

KH 7

Catalog #: 3834
9 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3834/10
3834/50
KH 7 | CAS No. 330676-02-3 | Adenylyl Cyclase Inhibitors
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Description: Selective soluble adenylyl cyclase inhibitor

Chemical Name: (±)-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide

Purity: ≥99%

Product Details
Citations (9)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

KH 7 is a selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM.

Technical Data

M.Wt:
419.3
Formula:
C17H15BrN4O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
330676-02-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Amyloid beta (Abeta) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways.
    Fu W, Ruangkittisakul A, MacTavish D, Shi JY, Ballanyi K, Jhamandas JH
    J. Biol. Chem., 2012;287(22):18820-30.
  2. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks D, Germain R, Kastner D, Chae J
    Nature, 2012;492(7427):123-7.
  3. Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages.
    Sokolowska M, Chen L, Liu Y, Martinez-Anton A, Qi H, Logun C, Alsaaty S, Park Y, Kastner D, Chae J, Shelhamer J
    J Immunol, 2015;194(11):5472-87.
  4. Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion
    C Silva-Vilc, K Pletinckx, M Lohnert, V Pavlovic, D Ashour, V John, E Vendelova, S Kneitz, J Zhou, R Chen, T Reinheckel, TD Mueller, J Bodem, MB Lutz
    PLoS ONE, 2017;12(7):e0178114.
  5. Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells.
    Kumar et al.
    J.Biol.Chem., 2009;284:14760
  6. Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1.
    Stessin et al.
    J.Biol.Chem., 2006;281:17253
  7. The 'soluble' adenylyl cyclase in sperm mediates multiple signaling events required for fertilization.
    Hess et al.
    Develop.Cell, 2005;9:249

Product Datasheets

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Citations for KH 7

The citations listed below are publications that use Tocris products. Selected citations for KH 7 include:

9 Citations: Showing 1 - 9

  1. Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia.
    Authors: Schnúr Et al.
    Sci Rep  2019;9:12706
  2. An improved method for isolation of mitochondria from cell lines that enables reconstitution of calcium-dependent processes.
    Authors: Ishii Et al.
    Anal Biochem  2019;577:52
  3. Reconsideration of the evaluation criteria for bull ejaculated sperm motility in the context of rotation.
    Authors: Yamada Et al.
    J Reprod Dev  2018;64:377
  4. cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells.
    Authors: Inda Et al.
    Sci Rep  2017;7:1944
  5. Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling.
    Authors: Inda Et al.
    J Cell Biol  2016;214:181
  6. Nonpigmented ciliary epithelial cells respond to acetazol. by a soluble adenylyl cyclase mechanism.
    Authors: Shahidullah Et al.
    Invest Ophthalmol Vis Sci  2014;55:187
  7. Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway.
    Authors: Chen Et al.
    Mediators Inflamm  2013;9:2033
  8. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
    Authors: Jahchan Et al.
    Cancer Discov  2013;3:1364
  9. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature  2012;492:123

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