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KJ Pyr 9

Catalog #: 5306
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5306/50
5306/10
KJ Pyr 9 | CAS No. 581073-80-5 | MYC Inhibitors
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Description: High affinity Myc inhibitor

Chemical Name: 4-[2-(2-Furanyl)-6-(4-nitrophenyl)-4-pyridinyl]benzamide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

KJ Pyr 9 is a high affinity Myc inhibitor (Kd = 6.5 nM). Disrupts Myc-Max interaction. Inhibits Myc-dependent cancer cell line proliferation in vitro. Inhibits growth of MDA-MB-231 breast cancer cell xenografts in mice. Brain penetrant.

Technical Data

M.Wt:
385.37
Formula:
C22H15N3O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
581073-80-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibitor of MYC identified in a Kröhnke pyridine library.
    Hart et al.
    Proc.Natl.Acad.Sci.U.S.A., 2014;111:12556

Product Datasheets

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Citations for KJ Pyr 9

The citations listed below are publications that use Tocris products. Selected citations for KJ Pyr 9 include:

2 Citations: Showing 1 - 2

  1. Acute liver failure is regulated by MYC- and microbiome-dependent programs.
    Authors: Ana Et al.
    Nat Med  2020;26:1899-1911
  2. Downregulation of ribosome biogenesis during early forebrain development.
    Authors: Chau Et al.
    Elife.  2018;:e36998

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