L-NIO dihydrochloride
Chemical Name: N5-(1-Iminoethyl)-L-ornithine dihydrochloride
Biological Activity
L-NIO dihydrochloride is an Inhibitor of nitric oxide (NO) synthase. Inhibits iNOS, eNOS and nNOS. Active in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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XIV. International Union of Pharmacology nomenclature in nitric oxide research.
Moncada et al.
Pharmacol.Rev., 1997;49:137 -
Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis.
Mulligan et al.
Br.J.Pharmacol., 1992;107:1159 -
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.
Rees et al.
Br.J.Pharmacol., 1990;101:746
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Citations for L-NIO dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for L-NIO dihydrochloride include:
8 Citations: Showing 1 - 8
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Relaxin peptide hormones are protective during the early stages of ischemic stroke in male rats.
Authors: Bergeron Et al.
PLoS Negl Trop Dis 2015;156:638
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Neuronal and Endothelial Nitric Oxide Synthases in the Paraventricular Nucleus Modulate Sympathetic Overdrive in Ins-Resistant Rats.
Authors: Lu Et al.
Endocrinology 2015;10:e0140762
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Neuronal nitric oxide synthase-dependent elevation in adiponectin in the rostral ventrolateral medulla underlies g protein-coupled receptor 18-mediated hypotension in conscious rats.
Authors: Penumarti and Abdel-Rahman
J Pharmacol Exp Ther 2014;351:44
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Vasorelaxin: a novel arterial smooth muscle-relaxing eicosapeptide from the skin secretion of the Chinese piebald odorous frog (Odorrana schmackeri).
Authors: Wu Et al.
PLoS One 2013;8:e55739
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Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts.
Authors: Gross Et al.
J Mol Cell Cardiol 2013;59:20
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Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS.
Authors: Dai Et al.
Am J Physiol Heart Circ Physiol 2011;301:H1248
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Differential central NOS-NO signaling underlies clon. exacerbation of ethanol-evoked behavioral impairment.
Authors: Bender and Abdel-Rahman
Alcohol Clin Exp Res 2010;34:555
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Differential contributions of nitric oxide synthase isoforms at hippocampal formation to negative feedback regulation of penile erection in the rat.
Authors: Chang Et al.
Br J Pharmacol 2002;136:43313
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