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Latrunculin B

Catalog #: 3974
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3974/1
Latrunculin B | CAS No. 76343-94-7 | Actin-related Products
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Description: Inhibitor of actin polymerization

Chemical Name: (4R)-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone

Purity: ≥95%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Latrunculin B is an inhibitor of actin polymerization. Interacts with G-actin in a 1:1 ratio to inhibit polymerization into F-actin in vitro (IC50 values are ~60 and ~900 nM in absence and presence of calf serum, respectively). Marine toxin.

Technical Data

M.Wt:
395.51
Formula:
C20H29NO5S
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
76343-94-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of cytochalasin D and latrunculin B on mechanical properties of cells.
    Wakatsuki et al.
    J.Cell.Sci., 2001;114:1025

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Citations for Latrunculin B

The citations listed below are publications that use Tocris products. Selected citations for Latrunculin B include:

5 Citations: Showing 1 - 5

  1. Gamma oscillations in the pedunculopontine nucleus are regulated by F-actin: neuroepigenetic implications.
    Authors: Verónica Et al.
    Am J Physiol Cell Physiol  2020;318:C282-C288
  2. MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis.
    Authors: Ying Et al.
    Nat Commun  2020;11:3151
  3. Short-Term Plasticity at Hippocampal Mossy Fiber Synapses Is Induced by Natural Activity Patterns and Associated with Vesicle Pool Engram Formation.
    Authors: Xiaomin Et al.
    Neuron  2020;107:509-521.e7
  4. Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle.
    Authors: Mart Et al.
    Mol Cell  2019;75:76-89.e3
  5. A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport.
    Authors: Zheng Et al.
    Cell Rep  2019;28:3224-3237.e5

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